Mfon E. Umoh

TL;DR: BioID uses proximity-dependent biotin identification to interrogate the interactome of detergent-insoluble TDP-43 aggregates and finds them enriched for components of the nuclear pore complex and nucleocytoplasmic transport machinery.

TL;DR: A module enriched with astrocyte and microglia proteins was significantly increased in ALS cases carrying the C9orf72 mutation compared to sporadic ALS cases, suggesting that the genetic expansion is associated with inflammation in the brain even without clinical evidence of dementia.

TL;DR: Assessing family history for dementia may identify other family members likely to be carrying the C9orf72 expansion, reduce the number of sporadic cases, and thus increase the understanding of disease penetrance.

TL;DR: BioID used to interrogate the interactome of detergent-insoluble TDP-43 aggregates found them enriched for components of the nuclear pore complex (NPC) and nucleocytoplasmic transport machinery.

TL;DR: In this paper , the authors examined the longitudinal association between the access and use of technology and social isolation in older adults living in the United States, and found that technology is increasingly thought of as a solution to address social isolation.