Spencer Vaughan

TL;DR: BioID uses proximity-dependent biotin identification to interrogate the interactome of detergent-insoluble TDP-43 aggregates and finds them enriched for components of the nuclear pore complex and nucleocytoplasmic transport machinery.

TL;DR: Cerebral palsy risk genes in enriched pathways were shown to regulate neuromotor function in a Drosophila reverse genetics screen, providing evidence for genetically mediated dysregulation of early neuronal connectivity in cerebral palsy.

TL;DR: It is demonstrated that endocytosis is also important for regulating TDP-43 turnover and toxicity, which may be an underlying cause of ALS pathology.