M
Mia Buehr
Researcher at University of Edinburgh
Publications - 8
Citations - 1355
Mia Buehr is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 8 publications receiving 1311 citations.
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Journal ArticleDOI
Capture of Authentic Embryonic Stem Cells from Rat Blastocysts
Mia Buehr,Stephen Meek,Kate Blair,Kate Blair,Jian Yang,Jian Yang,Janice Ure,José C. R. Silva,José C. R. Silva,Renee McLay,John Simon Hall,John Simon Hall,Qi-Long Ying,Austin Smith,Austin Smith +14 more
TL;DR: Derivation of germline-competent ES cells from the rat paves the way to targeted genetic manipulation in this valuable biomedical model species and will also provide a refined test-bed for functional evaluation of pluripotent stem cell-derived tissue repair and regeneration.
Journal ArticleDOI
Rapid Loss of Oct-4 and Pluripotency in Cultured Rodent Blastocysts and Derivative Cell Lines
Mia Buehr,Jennifer Nichols,Frances H. Stenhouse,Peter Scott Mountford,C.J. Greenhalgh,Surasak Kantachuvesiri,Gillian Brooker,John J. Mullins,Austin Smith +8 more
TL;DR: Downregulation of Oct-4 appears to be a limiting factor in attempts to derive pluripotent cell lines from preimplantation embryos.
Journal ArticleDOI
Genesis of embryonic stem cells.
Mia Buehr,Austin Smith +1 more
TL;DR: The findings suggest that the genesis of an ES cell is a relatively complex process requiring epigenetic modulation of key gene expression over a brief time- window, and procedures that extend this time-window and/or directly regulate the critical genes should increase the efficiency of ES cell derivation.
Journal ArticleDOI
Size regulation in chimaeric mouse embryos.
Mia Buehr,Anne McLaren +1 more
TL;DR: The comparison suggests that growth regulation in the 'double' embryos takes place fairly rapidly, after the formation of the egg cylinder but before the appearance of the pro-amniotic cavity.