Mian Long

TL;DR: It is shown that increasing force first prolonged and then shortened the lifetimes of P-selectin complexes with P- selectin glycoprotein ligand-1, revealing both catch and slip bond behaviour.

TL;DR: This 3D-configured in vitro liver chip integrates the two key factors of shear flow and the four types of primary hepatic cells to replicate key structures, hepatic functions, and primary immune responses and provides a new in vitro model to investigate the short-duration hepatic cellular interactions under a microenvironment mimicking the physiology of a liver.

TL;DR: A micro-fabricated polyacrylamide hydrogel substrate with two elasticities, two topographies, and three dimensions was applied to systematically test proliferation, morphology and spreading, differentiation, and cytoskeletal re-organization of rat bone marrow mesenchymal stem cells (rBMSCs) and an isolated but not combinatory impact of the factors was found regarding the specific functions.

TL;DR: A micro-fabricated polyacrylamide hydrogel substrate with two elasticities and three topographies was applied to systematically test the morphology, proliferation, and stemness of mESCs and the independent or combined impact of the two factors on specific cell functions was analyzed.

TL;DR: It is demonstrated that the orientation and length of an adhesion receptor influences its rate of encountering and binding a surface ligand but does not subsequently affect the stability of binding.