M
Michael A. Cater
Researcher at Centre for Cellular and Molecular Biology
Publications - 34
Citations - 2744
Michael A. Cater is an academic researcher from Centre for Cellular and Molecular Biology. The author has contributed to research in topics: ATP7A & Copper. The author has an hindex of 21, co-authored 34 publications receiving 2230 citations. Previous affiliations of Michael A. Cater include Deakin University & Mental Health Research Institute.
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Journal ArticleDOI
Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
James A. Duce,Andrew Tsatsanis,Michael A. Cater,Simon James,Elysia Robb,Krutika Wikhe,Su Ling Leong,Keyla Perez,Timothy Johanssen,Mark Greenough,Hyun-Hee Cho,Denise Galatis,Robert D. Moir,Colin L. Masters,Catriona McLean,Rudolph E. Tanzi,Roberto Cappai,Kevin J. Barnham,Giuseppe D. Ciccotosto,Jack T. Rogers,Jack T. Rogers,Ashley I. Bush +21 more
TL;DR: This article found that the AD β-amyloid protein precursor possesses ferroxidase activity mediated by a conserved H-ferritin-like active site, which is inhibited specifically by endogenous Zn(2+)-laden amyloid aggregates and correlates with Aβ burden.
Journal ArticleDOI
Targeting copper in cancer therapy: ‘Copper That Cancer’
Delphine Denoyer,Shashank Masaldan,Sharon La Fontaine,Sharon La Fontaine,Michael A. Cater,Michael A. Cater +5 more
TL;DR: The biological importance of copper and copper homeostasis in mammalian cells is outlined, followed by a discussion of the current understanding of copper dysregulation in cancer, and the recent therapeutic advances using copper coordination complexes as anticancer agents.
Journal ArticleDOI
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.
Shashank Masaldan,Sharnel A.S. Clatworthy,Cristina Gamell,Peter M. Meggyesy,Antonia Tonia Rigopoulos,Sue Haupt,Ygal Haupt,Delphine Denoyer,Paul A. Adlard,Ashley I. Bush,Michael A. Cater,Michael A. Cater +11 more
TL;DR: It is reported that senescence alters cellular iron acquisition and storage and also impedes iron-mediated cell death pathways, and senescent cells were highly resistant to ferroptosis.
Journal ArticleDOI
Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate.
Michael J. Petris,Ilia Voskoboinik,Michael A. Cater,Kathryn Smith,Byung-Eun Kim,Roxana M. Llanos,Daniel Strausak,James Camakaris,Julian F.B. Mercer +8 more
TL;DR: The findings suggest that the copper-induced trafficking of the Menkes and Wilson disease copper ATPases is associated with the phosphorylated intermediate that is formed during the catalysis of these pumps.
Journal ArticleDOI
ATP7B Mediates Vesicular Sequestration of Copper: Insight Into Biliary Copper Excretion
TL;DR: It is provided compelling evidence that the primary mechanism of biliary copper excretion involves ATP7B-mediated vesicular sequestration of copper rather than direct copper translocation across the canalicular membrane.