M
Michael A. Heneghan
Researcher at University of Cambridge
Publications - 289
Citations - 10869
Michael A. Heneghan is an academic researcher from University of Cambridge. The author has contributed to research in topics: Liver transplantation & Autoimmune hepatitis. The author has an hindex of 51, co-authored 245 publications receiving 9041 citations. Previous affiliations of Michael A. Heneghan include National Health Service & King's College.
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Journal ArticleDOI
Towards personalised medicine in autoimmune hepatitis: Measurement of thiopurine metabolites results in higher biochemical response rates
Lena S. Candels,Lena S. Candels,Mussarat N. Rahim,Mussarat N. Rahim,Sital Shah,Michael A. Heneghan,Michael A. Heneghan +6 more
TL;DR: In this paper, the authors evaluated the benefits of a personalised medicine approach to thiopurine dosing, in comparison to standard weight-based dosing and found that patients with metabolite monitoring experienced fewer adverse drug reactions (ADRs).
Journal ArticleDOI
Patient perception of skin-cancer prevention and risk after liver transplantation.
B. R. Thomas,A. Barnabas,Kosh Agarwal,Varuna Aluvihare,Abid Suddle,Elisabeth Higgins,J.G. O'Grady,Nigel Heaton,Michael A. Heneghan +8 more
TL;DR: Sun exposure is a major risk factor for the development of skin cancer in immunosuppressed liver‐transplant recipients (LTRs), and preventative strategies may help minimize the skin‐cancer risk in this patient group.
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Impact of comorbidity on waiting list and post-transplant outcomes in patients undergoing liver retransplantation.
M Al-Freah,Carl Moran,Matthew R. Foxton,Kosh Agarwal,Julia Wendon,Nigel Heaton,Michael A. Heneghan +6 more
TL;DR: Comorbidity increases WL and post-LRT mortality and patients with MELD ≥ 18 have increased WL mortality and may benefit from earlier LRT, while LRT for ≥ 3 grafts may not represent appropriate use of donated grafts.
Journal ArticleDOI
Change in model for end-stage liver disease score on the transplant waiting list predicts survival in patients undergoing liver transplantation
Matthew R. Foxton,Stewart Kendrick,Elizabeth Sizer,Paolo Muiesan,M Rela,Julia Wendon,Nigel Heaton,John O'Grady,Michael A. Heneghan +8 more
TL;DR: It is concluded that change in MELD score whilst on the transplant waiting list has a significant effect on survival post‐transplant although MELD Score at the time of transplant appears to have the most significant impact on resource utilization.
Journal ArticleDOI
Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action.
Caroline Ovadia,Anita Lövgren-Sandblom,Lindsey A. Edwards,Jacqueline Langedijk,Victoria Geenes,Jenny Chambers,Jenny Chambers,Floria Cheng,Louise C. D. Clarke,Shahina Begum,Muna Noori,Charles D. Pusey,Radhika Padmagirison,Sangita Agarwal,James Peerless,Kate Cheesman,Michael A. Heneghan,Ronald P.J. Oude Elferink,Vishal C. Patel,Hanns-Ulrich Marschall,Catherine Williamson +20 more
TL;DR: It is hypothesised that therapeutic plasma exchange removes pruritogens and lowers total bile acid concentrations, and improves symptoms and biochemical abnormalities in severe cases that have not responded to other treatments.