M
Michael A. Palladino
Researcher at Nereus Pharmaceuticals
Publications - 177
Citations - 19198
Michael A. Palladino is an academic researcher from Nereus Pharmaceuticals. The author has contributed to research in topics: Proteasome inhibitor & Bortezomib. The author has an hindex of 57, co-authored 176 publications receiving 18857 citations. Previous affiliations of Michael A. Palladino include Genentech & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
Diane Pennica,Glenn Evan Nedwin,Joel S. Hayflick,Peter H. Seeburg,Rik Derynck,Michael A. Palladino,William J. Kohr,Bharat B. Aggarwal,David V. Goeddel +8 more
TL;DR: Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
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Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro
B. J. Sugarman,Bharat B. Aggarwal,Philip E. Hass,I S Figari,Michael A. Palladino,H. M. Shepard +5 more
TL;DR: The observations indicate that the effects of rTNF-alpha on cell growth are not limited to tumor cells, but rather that this protein may have a broad spectrum of activities in vivo.
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Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Charles A. Dinarello,Joseph G. Cannon,Sheldon M. Wolff,H A Bernheim,Bruce Beutler,Anthony Cerami,Irene S. Figari,Michael A. Palladino,O'connor John +8 more
TL;DR: These studies show that TNF (cachectin) is another endogenous pyrogen which, like IL-1 and IFN-alpha, directly stimulate hypothalamic PGE2 synthesis and is an endogenous inducer ofIL-1.
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The two different receptors for tumor necrosis factor mediate distinct cellular responses.
Louis A. Tartaglia,Richard F. Weber,I S Figari,Carmen Reynolds,Michael A. Palladino,David V. Goeddel +5 more
TL;DR: Investigation of the individual roles of the murine type 1 and type 2 tumor necrosis factor (TNF) receptors suggest that TNF-R2 initiates signals for the proliferation of thymocytes and cytotoxicity and the induction of the protective activity, manganous superoxide dismutase.
Journal Article
Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.
M R Shalaby,Bharat B. Aggarwal,E Rinderknecht,L. P. Svedersky,B. S. Finkle,Michael A. Palladino +5 more
TL;DR: Although lipopolysaccharide (LPS) is a potent stimulator of PMN function, polymyxin B can block LPS-induced but not lymphokine-induced activation, demonstrating new activities for both TNF-alpha and T NF-beta in augmenting the phagocytic and cytotoxic activities of PMn.