D
Diane Pennica
Researcher at Genentech
Publications - 149
Citations - 16166
Diane Pennica is an academic researcher from Genentech. The author has contributed to research in topics: Cardiotrophin 1 & Glycoprotein 130. The author has an hindex of 51, co-authored 149 publications receiving 15870 citations. Previous affiliations of Diane Pennica include Roche Institute of Molecular Biology & University of California.
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Journal ArticleDOI
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
Diane Pennica,Glenn Evan Nedwin,Joel S. Hayflick,Peter H. Seeburg,Rik Derynck,Michael A. Palladino,William J. Kohr,Bharat B. Aggarwal,David V. Goeddel +8 more
TL;DR: Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
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Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
Diane Pennica,William E. Holmes,William J. Kohr,Richard N. Harkins,Gordon A. Vehar,Carole A. Ward,William F. Bennett,Elizabeth Mcleod Yelverton,Peter H. Seeburg,Herbert L. Heyneker,David V. Goeddel,Desire Collen +11 more
TL;DR: Bacterial clones containing human tissue-type plasminogen activator cDNA sequences were identified in a cDNA library prepared using gel-fractionated mRNA from human melanoma cells and a polypeptide was produced having the fibrinolytic properties characteristic of authentic human t-PA.
Journal ArticleDOI
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
Donna M. Stone,Mary Hynes,Mark Armanini,Todd A. Swanson,Qimin Gu,Ronald L. Johnson,Matthew P. Scott,Diane Pennica,Audrey Goddard,Heidi S. Phillips,Markus Noll,Joan E. Hooper,Frederic J. de Sauvage,Arnon Rosenthal +13 more
TL;DR: It is shown that Re can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly.
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Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
Scott J. Rodig,Marco A Meraz,J. Michael White,Pat A Lampe,Joan K. Riley,Cora D. Arthur,Kathleen L. King,Kathleen C. F. Sheehan,Li Yin,Diane Pennica,Eugene M. Johnson,Robert D. Schreiber +11 more
TL;DR: The generation of mice lacking the ubiquitously expressed Janus kinase, Jak1, demonstrate that Jak1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which Jak utilization was thought to be nonspecific.
Journal ArticleDOI
Expression of human immune interferon cDNA in E. coli and monkey cells
Patrick W. Gray,David W. Leung,Diane Pennica,Elizabeth Mcleod Yelverton,Richard Najarian,Christian C. Simonsen,Rik Derynck,Pamela J. Sherwood,Donald M. Wallace,Shelby L. Berger,Arthur D. Levinson,David V. Goeddel +11 more
TL;DR: The polypeptide produced through expression of this DNA sequence in Escherichia coli or cultured monkey cells had properties characteristic of authentic human IFN-γ.