M
Michael A. Saunders
Researcher at Stanford University
Publications - 200
Citations - 37808
Michael A. Saunders is an academic researcher from Stanford University. The author has contributed to research in topics: Nonlinear programming & Constrained optimization. The author has an hindex of 59, co-authored 194 publications receiving 34804 citations. Previous affiliations of Michael A. Saunders include Carleton University & University of California, San Diego.
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Quadruple-precision solution of genome-scale models of Metabolism and macromolecular Expression
Ding Ma,Laurence Yang,Ronan M. T. Fleming,Ines Thiele,Bernhard O. Palsson,Michael A. Saunders +5 more
TL;DR: A quadruple-precision version of the linear and nonlinear optimizer MINOS, and a solution procedure involving Double and Quad MINOS that balances efficiency and reliability for ME models.
Posted ContentDOI
Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism
German Preciat,Edinson Lucumi Moreno,Agnieszka B. Wegrzyn,Cornelius C.W. Willacey,Jennifer Modamio,Fatima L. Monteiro,Diana C. El Assal,Alissa Schurink,Miguel A.P. Oliveira,Zhi Zhang,Ben Cousins,Ben Cousins,Hulda S. Haraldsdóttir,Susanne Zach,Santosh Vempala,Bastian Hengerer,Michael A. Saunders,Amy C. Harms,Jens Christian Schwamborn,Ines Thiele,Thomas Hankemeier,Ronan M. T. Fleming,Ronan M. T. Fleming +22 more
TL;DR: In this article, a high-quality, constraint-based, genome-scale, in silico model of human dopaminergic neuronal metabolism (iDopaNeuro1) is generated.
Journal ArticleDOI
Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study
Calum A. MacRae,Matthew D. Taylor,Luisa Mestroni,J Moses,Euan A. Ashley,Matthew T. Wheeler,Neal K. Lakdawala,Ray E. Hershberger,Victor Sandor,Michael A. Saunders,Colleen Oliver,Patrice Lee,Daniel P. Judge +12 more
TL;DR: In this article, the effects of the oral selective p38 mitogen-activated protein kinase inhibitor ARRY-371797 on functional capacity and cardiac function in patients with LMNA-related dilated cardiomyopathy were evaluated.
Posted Content
Compile-Time Symbolic Differentiation Using C++ Expression Templates
TL;DR: It is demonstrated how expression templates can be used for compile time symbolic differentiation of algebraic expressions in C++ computer programs using recursive templates.
Transformed Hessian methods for large-scale constrained optimization
TL;DR: In this article, the authors define the transformed Hessian and discuss its role in sequential quadratic programming (SQP) methods for constrained optimization, where nonlinear inequality constraints are usually converted to equalities by adding bounded slack variables.