M
Matthew T. Wheeler
Researcher at Stanford University
Publications - 216
Citations - 10130
Matthew T. Wheeler is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 170 publications receiving 7757 citations. Previous affiliations of Matthew T. Wheeler include Cardiovascular Institute of the South & Williams College.
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Journal ArticleDOI
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.
David L. Boone,Emre E. Turer,Eric Lee,Regina Celeste Ahmad,Matthew T. Wheeler,Colleen Tsui,Paula J. Hurley,Marcia Chien,Sophia Chai,Osamu Hitotsumatsu,Elizabeth M. McNally,Cecile M. Pickart,Averil Ma +12 more
TL;DR: A20 was required for the termination of Toll-like receptor–induced activity of the transcription factor NF-κB and proinflammatory gene expression in macrophages, and this function protected mice from endotoxic shock, indicating that A20 is also critical for the regulation of TNF-independent signals in vivo.
Journal ArticleDOI
Clinical assessment incorporating a personal genome
Euan A. Ashley,Atul J. Butte,Matthew T. Wheeler,Rong Chen,Teri E. Klein,Frederick E. Dewey,Joel T. Dudley,Kelly E. Ormond,Aleksandra Pavlovic,Alexander A. Morgan,Dmitry Pushkarev,Norma F. Neff,Louanne Hudgins,Li Gong,Laura M. Hodges,Dorit S. Berlin,Caroline F. Thorn,Katrin Sangkuhl,Joan M. Hebert,Mark Woon,Hersh Sagreiya,Ryan Whaley,Joshua W. Knowles,Michael F. Chou,Joseph V. Thakuria,Abraham M. Rosenbaum,Alexander Wait Zaranek,George M. Church,Henry T. Greely,Stephen R. Quake,Russ B. Altman +30 more
TL;DR: Although challenges remain, the results suggest that whole-genome sequencing can yield useful and clinically relevant information for individual patients.
Journal ArticleDOI
Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Feng Lan,Andrew S. Lee,Ping Liang,Veronica Sanchez-Freire,Patricia K. Nguyen,Li Wang,Leng Han,Michelle Yen,Yongming Wang,Ning Sun,Oscar J. Abilez,Shijun Hu,Antje D. Ebert,Enrique G. Navarrete,Chelsey S. Simmons,Matthew T. Wheeler,Beth L. Pruitt,Richard S. Lewis,Yoshinori Yamaguchi,Euan A. Ashley,Donald M. Bers,Robert C. Robbins,Michael T. Longaker,Joseph C. Wu +23 more
TL;DR: Patients generating patient-specific induced pluripotent stem cell cardiomyocytes from a ten-member family cohort carrying a hereditary HCM missense mutation (Arg663His) in the MYH7 gene are generated to help elucidate the mechanisms underlying HCM development and identify novel therapies for the disease.
Journal ArticleDOI
Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources
Sebastian Köhler,Leigh C. Carmody,Nicole Vasilevsky,Julius O.B. Jacobsen,Daniel Danis,Jean-Philippe F. Gourdine,Michael A. Gargano,Nomi L. Harris,Nicolas Matentzoglu,Julie A. McMurry,David Osumi-Sutherland,Valentina Cipriani,James P. Balhoff,Tom Conlin,Hannah Blau,Gareth Baynam,Richard Palmer,Dylan Gratian,Hugh Dawkins,Michael M. Segal,Anna Jansen,Ahmed Muaz,Willie H. Chang,Jenna R.E. Bergerson,Stanley J. F. Laulederkind,Zafer Yüksel,Sergi Beltran,Alexandra F. Freeman,Panagiotis I. Sergouniotis,Daniel Durkin,Andrea L. Storm,Marc Hanauer,Michael Brudno,Susan M. Bello,Murat Sincan,Kayli Rageth,Matthew T. Wheeler,Renske Oegema,Halima Lourghi,Maria G. Della Rocca,Rachel Thompson,Francisco Castellanos,James R. Priest,Charlotte Cunningham-Rundles,Ayushi Hegde,Ruth C. Lovering,Catherine Hajek,Annie Olry,Luigi D. Notarangelo,Morgan Similuk,Xingmin Aaron Zhang,David Gómez-Andrés,Hanns Lochmüller,Hélène Dollfus,Sergio Rosenzweig,Shruti Marwaha,Ana Rath,Kathleen E. Sullivan,Cynthia L. Smith,Joshua D. Milner,Dorothée Leroux,Cornelius F. Boerkoel,Amy D. Klion,Melody C. Carter,Tudor Groza,Damian Smedley,Melissa A. Haendel,Melissa A. Haendel,Christopher J. Mungall,Peter N. Robinson +69 more
TL;DR: The HPO’s interoperability with other ontologies has enabled it to be used to improve diagnostic accuracy by incorporating model organism data and plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data.
Journal ArticleDOI
Clinical Interpretation and Implications of Whole-Genome Sequencing
Frederick E. Dewey,Megan E. Grove,Cuiping Pan,Benjamin A. Goldstein,Jonathan A. Bernstein,Hassan Chaib,Jason D. Merker,Rachel L. Goldfeder,Gregory M. Enns,Sean P. David,Neda Pakdaman,Kelly E. Ormond,Colleen Caleshu,Kerry Kingham,Teri E. Klein,Michelle Whirl-Carrillo,Kenneth Sakamoto,Matthew T. Wheeler,Atul J. Butte,James M. Ford,Linda M. Boxer,John P. A. Ioannidis,Alan C. Yeung,Alan C. Yeung,Russ B. Altman,Themistocles L. Assimes,Themistocles L. Assimes,Michael Snyder,Michael Snyder,Euan A. Ashley,Thomas Quertermous +30 more
TL;DR: The use of WGS was associated with incomplete coverage of inherited disease genes, low reproducibility of detection of genetic variation with the highest potential clinical effects, and uncertainty about clinically reportable findings.