M
Michael August
Researcher at University of Mainz
Publications - 10
Citations - 1801
Michael August is an academic researcher from University of Mainz. The author has contributed to research in topics: Superoxide & Nitric oxide. The author has an hindex of 10, co-authored 10 publications receiving 1727 citations. Previous affiliations of Michael August include University of Hamburg.
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Journal ArticleDOI
Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling
Hanke Mollnau,Maria Wendt,Katalin Szöcs,Bernard Lassègue,Eberhard Schulz,Mathias Oelze,Huige Li,Martin Bodenschatz,Michael August,Andrei L. Kleschyov,Nikolaus Tsilimingas,Ulrich Walter,Ulrich Förstermann,Thomas Meinertz,Kathy K. Griendling,Thomas Münzel +15 more
TL;DR: It is concluded that angiotensin II-induced increases in the activity and the expression of NAD(P)H oxidase are at least in part PKC-dependent and may trigger NOS III uncoupling, leading to impaired NO/cGMP signaling and to endothelial dysfunction in this animal model.
Journal ArticleDOI
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
Karsten Sydow,Andreas Daiber,Matthias Oelze,Zhiqiang Chen,Michael August,Maria Wendt,Volker Ullrich,Alexander Mülsch,Eberhard Schulz,John F. Keaney,Jonathan S. Stamler,Thomas Münzel +11 more
TL;DR: Nitrate tolerance is mediated, at least in significant part, by inhibition of vascular ALDH-2 and that mitochondrial ROS contribute to this inhibition, and GTN tolerance may be viewed as a metabolic syndrome characterized by mitochondrial dysfunction.
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Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.
Andreas Daiber,Michael August,Stephan Baldus,Maria Wendt,Matthias Oelze,Karsten Sydow,Andrei L. Kleschyov,Thomas Münzel +7 more
TL;DR: Experiments using electron paramagnetic resonance and the spin trap 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide revealed that in contrast to lucigenin, L-012 is not subject to redox cycling.
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Reversal of Endothelial Nitric Oxide Synthase Uncoupling and Up-Regulation of Endothelial Nitric Oxide Synthase Expression Lowers Blood Pressure in Hypertensive Rats
Huige Li,Klaus Witte,Michael August,Isolde Brausch,Ute Gödtel-Armbrust,Alice Habermeier,Ellen I. Closs,Mathias Oelze,Thomas Münzel,Ulrich Förstermann +9 more
TL;DR: Pharmacologic interventions that combine eNOS up-regulation and reversal of eN OS uncoupling can markedly increase bioactive NO in the vasculature and produce beneficial hemodynamic effects such as a reduction of blood pressure.
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Nebivolol Prevents Vascular NOS III Uncoupling in Experimental Hyperlipidemia and Inhibits NADPH Oxidase Activity in Inflammatory Cells
Hanke Mollnau,Eberhard Schulz,Andreas Daiber,Stephan Baldus,Matthias Oelze,Michael August,Maria Wendt,Ulrich Walter,Carolin Geiger,Rahul Agrawal,Andrei L. Kleschyov,Thomas Meinertz,Thomas Münzel +12 more
TL;DR: Nebivolol therapy effectively prevents NO synthase III uncoupling and prevents activation of the neutrophil NAD(P)H oxidase and infiltration of inflammatory cells, which may explain partly the beneficial effects on endothelial function in patients with enhanced vascular oxidative stress.