Michael DeTure

TL;DR: NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.

TL;DR: This review outlines etiologically-linked pathologic features of Alzheimer's disease, as well as those that are inevitable findings of uncertain significance, such as granulovacuolar degeneration and Hirano bodies.

TL;DR: Co-expression and gene-association network analyses of gene expression and AS data revealed divergent pathways associated with c9 ALS and sALS, and heterogeneous nuclear ribonucleoprotein H (hnRNPH) and other RNA-binding proteins are predicted to be potential regulators of cassette exon AS events in both c9ALS and s ALS.

TL;DR: It is demonstrated that poly(GA) c9RAN proteins are neurotoxic and may be implicated in the neurodegenerative processes of c9FTD/ALS, and suggest that targeting the ER using small molecules may be a promising therapeutic approach for these devastating diseases.

TL;DR: The results suggest that the autophagic‐lysosomal system plays a role in the clearance of t Tau, and that dysfunction of this system results in the formation of tau oligomers and insoluble aggregates.