Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Karen S. SantaCruz,Jada Lewis,Tara L. Spires,Jennifer B. Paulson,Linda Kotilinek,Martin Ingelsson,A. Guimaraes,Michael DeTure,Martin Ramsden,Eileen McGowan,Colleen L. Forster,Mei Yue,Jennifer D. Orne,Chris Janus,Ami Mariash,Michael A. Kuskowski,Bradley T. Hyman,Mike Hutton,Karen H. Ashe +18 more
TLDR
NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.Abstract:
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathyread more
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