M
Michael A. Kuskowski
Researcher at University of Minnesota
Publications - 306
Citations - 25555
Michael A. Kuskowski is an academic researcher from University of Minnesota. The author has contributed to research in topics: Virulence & Population. The author has an hindex of 85, co-authored 306 publications receiving 23415 citations. Previous affiliations of Michael A. Kuskowski include Elsevier & United States Department of Veterans Affairs.
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Journal ArticleDOI
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Karen S. SantaCruz,Jada Lewis,Tara L. Spires,Jennifer B. Paulson,Linda Kotilinek,Martin Ingelsson,A. Guimaraes,Michael DeTure,Martin Ramsden,Eileen McGowan,Colleen L. Forster,Mei Yue,Jennifer D. Orne,Chris Janus,Ami Mariash,Michael A. Kuskowski,Bradley T. Hyman,Mike Hutton,Karen H. Ashe +18 more
TL;DR: NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy, and after the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to the authors' surprise, NFTs continued to accumulate.
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Natural oligomers of the amyloid-|[beta]| protein specifically disrupt cognitive function
James P. Cleary,Dominic M. Walsh,Dominic M. Walsh,J. Hofmeister,Ganesh M. Shankar,Michael A. Kuskowski,Michael A. Kuskowski,Dennis J. Selkoe,Karen H. Ashe,Karen H. Ashe +9 more
TL;DR: The biochemical isolation of discrete amyloid-β moieties with pathophysiological properties sets the stage for a new approach to studying the molecular mechanisms of cognitive impairment in Alzheimer disease and related neurodegenerative disorders.
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Escherichia coli Sequence Type ST131 as the Major Cause of Serious Multidrug-Resistant E. coli Infections in the United States
James R. Johnson,Brian Duncan Johnston,Connie Clabots,Michael A. Kuskowski,Mariana Castanheira +4 more
TL;DR: In this paper, the CTX-M-15 extended-spectrum beta-lactamase-associated Escherichia coli sequence type ST131 (O25:H4) has emerged internationally as a multidrug-resistant pathogen but has received little attention in the United States.
Journal ArticleDOI
C-Reactive Protein in Heart Failure Prognostic Value and the Effect of Valsartan
Inder S. Anand,Roberto Latini,Roberto Latini,Viorel G. Florea,Michael A. Kuskowski,Thomas S. Rector,Serge Masson,Stefano Signorini,Paolo Mocarelli,Allen Hester,Robert Glazer,Jay N. Cohn +11 more
TL;DR: Higher levels of CRP are associated with features of more severe heart failure and are independently associated with mortality and morbidity and the ability of treatments to reduce CRP levels and the prognostic importance of reducing CRP require further study.
Journal ArticleDOI
Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial.
Daniel D. Rhoads,Randall D. Wolcott,Michael A. Kuskowski,B M Wolcott,Loren S. Ward,A Sulakvelidze +5 more
TL;DR: This study found no safety concerns with the bacteriophage treatment, and effectiveness of the preparation will need to be evaluated in a phase II efficacy study.