M
Michael Devit
Publications - 5
Citations - 1048
Michael Devit is an academic researcher. The author has contributed to research in topics: Gene & Transthyretin. The author has an hindex of 4, co-authored 5 publications receiving 916 citations.
Papers
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Journal ArticleDOI
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
Christine Bulawa,Stephen Connelly,Michael Devit,Lan Wang,Charlotte Weigel,James Fleming,Jeff Packman,Evan T. Powers,R. Luke Wiseman,Ted R. Foss,Ian A. Wilson,Jeffery W. Kelly,Richard Labaudinière +12 more
TL;DR: The molecular and structural basis of TTR tetramer stabilization by tafamidis is described, suggesting that binding stabilizes the weaker dimer-dimer interface against dissociation, the rate-limiting step of amyloidogenesis.
Journal ArticleDOI
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Zhijian Li,Franco J. Vizeacoumar,Sondra Bahr,Jingjing Li,Jonas Warringer,Frederick S. Vizeacoumar,Renqiang Min,Benjamin VanderSluis,Jeremy Bellay,Michael Devit,James A. Fleming,Andrew D. Stephens,Julian Haase,Zhen Yuan Lin,Anastasia Baryshnikova,Hong Lu,Zhun Yan,Ke Jin,Sarah L. Barker,Alessandro Datti,Alessandro Datti,Guri Giaever,Corey Nislow,Chris Bulawa,Chad L. Myers,Michael Costanzo,Anne-Claude Gingras,Zhaolei Zhang,Anders Blomberg,Kerry Bloom,Brenda J. Andrews,Charles Boone +31 more
TL;DR: This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes, including roles for cohesin and condensin genes in spindle disassembly.
Patent
Modulation of protein trafficking
TL;DR: In this article, a method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.
Patent
Compounds and methods for modulating protein trafficking
Christine Bulawa,Michael Devit +1 more
TL;DR: In this article, compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking are presented, as well as methods for identification of compounds that rescue protein trafficking defects and methods of enhancing protein production.
Patent
Régulation du trafic de protéines
TL;DR: In this article, a procedure for traitement d'un trouble caracterise par un trafic de proteines deteriore comprend l'administration a un sujet ou le contact d'une cellule avec un compose de formule I [formule ici] ou ses sels pharmaceutiquement acceptables ou derives.