F
Frederick S. Vizeacoumar
Researcher at University of Saskatchewan
Publications - 57
Citations - 2012
Frederick S. Vizeacoumar is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 16, co-authored 46 publications receiving 1599 citations. Previous affiliations of Frederick S. Vizeacoumar include Lunenfeld-Tanenbaum Research Institute & Mount Sinai Hospital, Toronto.
Papers
More filters
Journal ArticleDOI
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Zhijian Li,Franco J. Vizeacoumar,Sondra Bahr,Jingjing Li,Jonas Warringer,Frederick S. Vizeacoumar,Renqiang Min,Benjamin VanderSluis,Jeremy Bellay,Michael Devit,James A. Fleming,Andrew D. Stephens,Julian Haase,Zhen Yuan Lin,Anastasia Baryshnikova,Hong Lu,Zhun Yan,Ke Jin,Sarah L. Barker,Alessandro Datti,Alessandro Datti,Guri Giaever,Corey Nislow,Chris Bulawa,Chad L. Myers,Michael Costanzo,Anne-Claude Gingras,Zhaolei Zhang,Anders Blomberg,Kerry Bloom,Brenda J. Andrews,Charles Boone +31 more
TL;DR: This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes, including roles for cohesin and condensin genes in spindle disassembly.
Journal ArticleDOI
Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Richard Marcotte,Kevin R. Brown,Fernando Suarez,Azin Sayad,Konstantina Karamboulas,Paul M. Krzyzanowski,Fabrice Sircoulomb,Mauricio Medrano,Yaroslav Fedyshyn,Judice L. Y. Koh,Dewald van Dyk,Bohdana Fedyshyn,Marianna Luhova,Glauber C. Brito,Franco J. Vizeacoumar,Frederick S. Vizeacoumar,Alessandro Datti,Dahlia Kasimer,Alla Buzina,Patricia Mero,Christine M. Misquitta,Josee Normand,Maliha Haider,Troy Ketela,Jeffrey L. Wrana,Robert Rottapel,Benjamin G. Neel,Jason Moffat +27 more
TL;DR: This study identified essential gene profiles in 72 breast, pancreatic, and ovarian cancer cell lines using a lentiviral shRNA library targeting ~16,000 genes and a newly developed, dynamic scoring approach, to facilitate the systematic identification of drivers, unanticipated synthetic lethal relationships, and functional vulnerabilities of these tumor types.
Journal ArticleDOI
Global Gene Deletion Analysis Exploring Yeast Filamentous Growth
Owen Ryan,Rebecca S. Shapiro,Christoph F. Kurat,David Mayhew,Anastasia Baryshnikova,Brian L. Chin,Zhen-Yuan Lin,Michael J. Cox,Frederick S. Vizeacoumar,Doris Cheung,Sondra Bahr,Kyle Tsui,Faiza Tebbji,Faiza Tebbji,Adnane Sellam,Adnane Sellam,Fabian Istel,Tobias Schwarzmüller,Todd B. Reynolds,Karl Kuchler,David K. Gifford,David K. Gifford,Malcolm Whiteway,Malcolm Whiteway,Guri Giaever,Corey Nislow,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Robi D. Mitra,Brenda J. Andrews,Gerald R. Fink,Gerald R. Fink,Leah E. Cowen,Charles Boone +34 more
TL;DR: This work constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain and identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth.
Journal ArticleDOI
Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors
Hong Han,Ulrich Braunschweig,Thomas Gonatopoulos-Pournatzis,Robert J. Weatheritt,Robert J. Weatheritt,Calley L. Hirsch,Kevin C.H. Ha,Ernest Radovani,Syed Nabeel-Shah,Timothy Sterne-Weiler,Juli Wang,Dave O'Hanlon,Qun Pan,Debashish Ray,Hong Zheng,Frederick S. Vizeacoumar,Alessandro Datti,Lilia Magomedova,Carolyn L. Cummins,Timothy P. Hughes,Jack Greenblatt,Jeffrey L. Wrana,Jeffrey L. Wrana,Jason Moffat,Benjamin J. Blencowe +24 more
TL;DR: A high-throughput system for systematically linking trans-acting factors to endogenous RNA regulatory events is described and hundreds of factors associated with diverse regulatory layers that positively or negatively control AS events linked to cell fate are identified.
Journal ArticleDOI
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis
Franco J. Vizeacoumar,Nydia Van Dyk,Frederick S. Vizeacoumar,Vincent Cheung,Jingjing Li,Yaroslav Sydorskyy,Nicolle Case,Zhijian Li,Alessandro Datti,Corey Nislow,Brian Raught,Zhaolei Zhang,Brendan J. Frey,Kerry Bloom,Charles Boone,Brenda J. Andrews +15 more
TL;DR: A combination of yeast genetics, synthetic genetic array analysis, and high-throughput screening reveals that sumoylation of Mcm21p promotes disassembly of the mitotic spindle.