M
Michael E. Rothenberg
Researcher at Stanford University
Publications - 32
Citations - 3118
Michael E. Rothenberg is an academic researcher from Stanford University. The author has contributed to research in topics: LGR5 & Stem cell. The author has an hindex of 19, co-authored 30 publications receiving 2740 citations. Previous affiliations of Michael E. Rothenberg include Genentech & University of California, San Francisco.
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Journal ArticleDOI
Single-cell dissection of transcriptional heterogeneity in human colon tumors
Piero Dalerba,Tomer Kalisky,Debashis Sahoo,Pradeep S. Rajendran,Michael E. Rothenberg,Anne A Leyrat,Sopheak Sim,Jennifer Okamoto,Jennifer Okamoto,Darius M. Johnston,Darius M. Johnston,Dalong Qian,Maider Zabala,Janet Bueno,Norma F. Neff,Jianbin Wang,Andrew A. Shelton,Brendan C. Visser,Shigeo Hisamori,Yohei Shimono,Marc van de Wetering,Hans Clevers,Michael F. Clarke,Stephen R. Quake,Stephen R. Quake +24 more
TL;DR: It is demonstrated that the transcriptional diversity of cancer tissues is largely explained by in vivo multilineage differentiation and not only by clonal genetic heterogeneity.
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Quantitative assessment of single-cell RNA-sequencing methods
Angela Ruohao Wu,Norma F. Neff,Tomer Kalisky,Piero Dalerba,Barbara Treutlein,Michael E. Rothenberg,Francis M. Mburu,Gary L. Mantalas,Sopheak Sim,Michael F. Clarke,Stephen R. Quake +10 more
TL;DR: It is shown that single-cell RNA-seq can be used to perform accurate quantitative transcriptome measurement in individual cells with a relatively small number of sequencing reads and that sequencing large numbers of single cells can recapitulate bulk transcriptome complexity.
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casanova Plays an Early and Essential Role in Endoderm Formation in Zebrafish
TL;DR: Although different populations of mesodermal precursors are generated normally in casanova mutants, morphogenetic defects in the heart, vasculature, blood, and kidney are apparent, suggesting a possible role for the endoderm in morphogenesis of these organs.
Journal ArticleDOI
Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice
Michael E. Rothenberg,Ysbrand Nusse,Tomer Kalisky,John J. Lee,Piero Dalerba,Ferenc A. Scheeren,Neethan A. Lobo,Subhash Kulkarni,Sopheak Sim,Dalong Qian,Philip A. Beachy,Philip A. Beachy,Pankaj J. Pasricha,Stephen R. Quake,Stephen R. Quake,Michael F. Clarke +15 more
TL;DR: Four major epithelial subtypes or transcriptional states were revealed by gene expression analysis of selected populations of single cells, and cKit marks small intestinal Paneth cells and a subset of colonic goblet cells that are regulated by Notch signaling and support Lgr5(+) stem cells.
Journal ArticleDOI
Partner of Numb Colocalizes with Numb during Mitosis and Directs Numb Asymmetric Localization in Drosophila Neural and Muscle Progenitors
TL;DR: It is proposed that PON is one component of a multimolecular machinery that localizes Numb by responding to polarity cues conserved in neural precursors and epithelial cells.