casanova Plays an Early and Essential Role in Endoderm Formation in Zebrafish
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TLDR
Although different populations of mesodermal precursors are generated normally in casanova mutants, morphogenetic defects in the heart, vasculature, blood, and kidney are apparent, suggesting a possible role for the endoderm in morphogenesis of these organs.About:
This article is published in Developmental Biology.The article was published on 1999-11-15 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Endoderm formation & Endoderm.read more
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Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
TL;DR: These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish and indicate that the endoderm, a tissue previously implicated in vascular development, provides a substratum for endothelial cell migration and is involved in regulating the timing of this process, but that it is not essential for the direction of migration.
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Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut.
TL;DR: The proposed KV is a transient embryonic `organ of asymmetry' that directs LR development by establishing a directional fluid flow and genetic analysis reveals novel roles for the T-box transcription factor no tail and the Nodal signaling pathway as upstream regulators of lrdr1 expression and KV morphogenesis.
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Ontogeny of the immune system of fish.
TL;DR: An early expression of Rag-1 is demonstrated in the zebrafish thymus that correlates well with the morphological identification of lymphoid cells, and the origins and time of appearance of B lymphocytes in teleosts are a matter of discussion.
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Molecular Genetics of Axis Formation in Zebrafish
TL;DR: The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of development, and how the coordinated interplay of molecules determines the fate and movement of embryonic cells is reviewed.
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Heart development: molecular insights into cardiac specification and early morphogenesis
TL;DR: This review attempts to identify areas in which additional research is needed to fully understand early cardiac development and the molecular control of left-right axis development has received particular attention.
References
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Basic Local Alignment Search Tool
TL;DR: A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score.
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Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
TL;DR: This paper describes the cloning and expression of a Xenopus homolog of Brachyury, Xbra, and shows that expression of Xbra occurs as a result of mesoderm induction in Xenopus, both in Response to the natural signal and in response to the Mesoderm-inducing factors activin A and basic FGF.
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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
TL;DR: An abundant cDNA enriched in Spemann's organizer, cerberus, encodes a secreted protein that is expressed in the anterior endomesoderm in the induction of head structures in the vertebrate embryo.
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The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling
Kira Gritsman,Jiaojiao Zhang,Simon Cheng,Elizabeth Heckscher,William S. Talbot,Alexander F. Schier +5 more
TL;DR: It is reported that embryos lacking both maternal and zygotic Oep activity are defective in germ layer formation, organizer development, and the positioning of the anterior-posterior axis.
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The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo.
TL;DR: The cloning and sequencing of the T gene in the zebrafish is reported and the nuclear localization of the protein product is shown, indicating high levels of expression are maintained throughout early development in the notochord.