P
Pankaj J. Pasricha
Researcher at Johns Hopkins University
Publications - 460
Citations - 20695
Pankaj J. Pasricha is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Gastroparesis & Gastric emptying. The author has an hindex of 69, co-authored 427 publications receiving 17988 citations. Previous affiliations of Pankaj J. Pasricha include Johns Hopkins University School of Medicine & University of Texas Medical Branch.
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Journal ArticleDOI
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
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A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development.
TL;DR: In this paper, the abdominal withdrawal reflex and responses of viscerosensitive neurons were recorded during colon distention in a rat with either mechanical or chemical colonic irritation between postnatal days 8 and 21 and were tested when they became adults.
Journal Article
Inhibition of apoptosis during development of colorectal cancer.
Atul Bedi,Pankaj J. Pasricha,Adil J. Akhtar,James Barber,Gauri C. Bedi,Francis M. Giardiello,Barbara A. Zehnbauer,Stanley R. Hamilton,Richard J. Jones +8 more
TL;DR: This data indicates that the transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis, which may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.
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Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
Joel T. Dudley,Marina Sirota,Marina Sirota,Mohan Shenoy,Reetesh K. Pai,Silke Roedder,Silke Roedder,Annie P. Chiang,Annie P. Chiang,Alexander A. Morgan,Alexander A. Morgan,Minnie M. Sarwal,Minnie M. Sarwal,Pankaj J. Pasricha,Atul J. Butte,Atul J. Butte +15 more
TL;DR: Experimental validation that an antiulcer drug and an antiepileptic can be reused for lung cancer and inflammatory bowel disease reinforces the promise of the computational approach to discover new drug therapies for IBD in silico.
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Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder
Paul Abrams,Karl-Erik Andersson,Jerry J. Buccafusco,Christopher R. Chapple,William C. de Groat,Alison D. Fryer,Gary Kay,Alan M. Laties,Neil M. Nathanson,Pankaj J. Pasricha,Alan J. Wein +10 more
TL;DR: The evolving understanding of muscarinic receptor functions throughout the body is explored, with particular focus on the bladder, gastrointestinal tract, eye, heart, brain and salivary glands, and the implications for drugs used to treat OAB.