M
Michael F. Chou
Researcher at Harvard University
Publications - 17
Citations - 2514
Michael F. Chou is an academic researcher from Harvard University. The author has contributed to research in topics: Phosphorylation & MAP2K7. The author has an hindex of 12, co-authored 17 publications receiving 2250 citations. Previous affiliations of Michael F. Chou include Wyss Institute for Biologically Inspired Engineering.
Papers
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Journal ArticleDOI
Clinical assessment incorporating a personal genome
Euan A. Ashley,Atul J. Butte,Matthew T. Wheeler,Rong Chen,Teri E. Klein,Frederick E. Dewey,Joel T. Dudley,Kelly E. Ormond,Aleksandra Pavlovic,Alexander A. Morgan,Dmitry Pushkarev,Norma F. Neff,Louanne Hudgins,Li Gong,Laura M. Hodges,Dorit S. Berlin,Caroline F. Thorn,Katrin Sangkuhl,Joan M. Hebert,Mark Woon,Hersh Sagreiya,Ryan Whaley,Joshua W. Knowles,Michael F. Chou,Joseph V. Thakuria,Abraham M. Rosenbaum,Alexander Wait Zaranek,George M. Church,Henry T. Greely,Stephen R. Quake,Russ B. Altman +30 more
TL;DR: Although challenges remain, the results suggest that whole-genome sequencing can yield useful and clinically relevant information for individual patients.
Reference EntryDOI
Biological Sequence Motif Discovery Using motif‐x
Michael F. Chou,Daniel Schwartz +1 more
TL;DR: The Web-based motif-x program provides a simple interface to extract statistically significant motifs from large data sets, such as MS/MS post-translational modification data and groups of proteins that share a common biological function.
Journal ArticleDOI
pLogo: a probabilistic approach to visualizing sequence motifs
TL;DR: The pLogo is described, a motif visualization in which residue heights are scaled relative to their statistical significance, in which real-time conditional probability calculations and visualizations are supported.
Journal ArticleDOI
Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
Sladjana Prisic,Selasi Dankwa,Daniel Schwartz,Michael F. Chou,Jason W. Locasale,Choong-Min Kang,Guy Bemis,George M. Church,Hanno Steen,Robert N. Husson +9 more
TL;DR: The Mycobacterium tuberculosis genome encodes 11 serine/threonine protein kinases (STPKs) that are structurally related to eukaryotic kinases, and an extensive analysis of protein phosphorylation in M. tuberculosis provides insight into processes regulated by STPKs in this major global pathogen.
Journal ArticleDOI
Recruitment of Xenopus Scc2 and Cohesin to Chromatin Requires the Pre-Replication Complex
TL;DR: A novel pre-RC-dependent pathway for cohesin recruitment to chromosomes in a vertebrate model system is defined, using Xenopus egg extracts to show that the recruitment of cohesins to chromosomes requires fully licensed chromatin and is dependent on ORC, Cdc6, Cdt1 and MCM2-7, but is independent of Cdk2.