M
Michael F. Hughes
Researcher at United States Environmental Protection Agency
Publications - 76
Citations - 6116
Michael F. Hughes is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Arsenic & Arsenate. The author has an hindex of 32, co-authored 76 publications receiving 5436 citations. Previous affiliations of Michael F. Hughes include Research Triangle Park & National Institutes of Health.
Papers
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Journal ArticleDOI
Arsenic toxicity and potential mechanisms of action
TL;DR: A better understanding of the mechanism(s) of action) of arsenic will make a more confident determination of the risks associated with exposure to this chemical.
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Arsenic Exposure and Toxicology: A Historical Perspective
TL;DR: The mode of action of arsenic for its disease endpoints is currently under study, and two key areas are the interaction of trivalent arsenicals with sulfur in proteins and the ability of arsenic to generate oxidative stress.
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Prostaglandin H synthase and xenobiotic oxidation.
TL;DR: In vivo investigations support the importance of the peroxidase and peroxyl radical systems in both activation and detoxification of chemicals in extrahepatic tissues.
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Biomarkers of exposure: a case study with inorganic arsenic.
TL;DR: Questions still remain, however, as to how reliably the measurement of urinary arsenic, either total or speciated, may predict arsenic concentrations at target tissues as well as how this measurement could be used to assess chronic exposures to iAs.
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The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency
Russell S. Thomas,Tina Bahadori,Timothy J. Buckley,John Cowden,Chad Deisenroth,Kathie L. Dionisio,Jeffrey B. Frithsen,Christopher M. Grulke,Maureen R. Gwinn,Joshua A. Harrill,Mark Higuchi,Keith A. Houck,Michael F. Hughes,E. Sidney Hunter,Kristin Isaacs,Richard S. Judson,Thomas B. Knudsen,Jason C. Lambert,Monica Linnenbrink,Todd M. Martin,Seth Newton,Stephanie Padilla,Grace Patlewicz,Katie Paul-Friedman,Katherine Phillips,Ann M. Richard,Reeder Sams,Timothy J. Shafer,R. Woodrow Setzer,Imran Shah,Jane Ellen Simmons,Steven O. Simmons,Amar V. Singh,Jon R. Sobus,Mark J. Strynar,Adam Swank,Rogelio Tornero-Valez,Elin M. Ulrich,Daniel L. Villeneuve,John F. Wambaugh,Barbara A. Wetmore,Antony J. Williams +41 more
TL;DR: The blueprint expands and refines the use of high-throughput and computational modeling approaches to transform the components in chemical risk assessment, while systematically addressing key challenges that have hindered progress.