Arsenic toxicity and potential mechanisms of action
TLDR
A better understanding of the mechanism(s) of action) of arsenic will make a more confident determination of the risks associated with exposure to this chemical.About:
This article is published in Toxicology Letters.The article was published on 2002-07-07 and is currently open access. It has received 1460 citations till now. The article focuses on the topics: Arsenic biochemistry & Arsenic toxicity.read more
Citations
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Book ChapterDOI
Heavy metal toxicity and the environment.
TL;DR: This review provides an analysis of arsenic, cadmium, chromium, lead, and mercury's environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity.
Journal ArticleDOI
Arsenic: toxicity, oxidative stress and human disease.
Klaudia Jomová,Zita Jenisová,Melánia Feszterová,Stanislav Baros,Líska J,Daniela Hudecová,Christopher J. Rhodes,Marian Valko +7 more
TL;DR: In this paper, the role of antioxidant defence systems against arsenic toxicity is discussed, and the role role of vitamin C (ascorbic acid), vitamin E (α-tocopherol), curcumin, glutathione and antioxidant enzymes such as superoxide dismutase, catalase, and peroxidase in their protective roles against arsenic-induced oxidative stress is also discussed.
Journal ArticleDOI
Arsenic as a Food Chain Contaminant: Mechanisms of Plant Uptake and Metabolism and Mitigation Strategies
TL;DR: A range of mitigation methods, from agronomic measures and plant breeding to genetic modification, may be employed to reduce As uptake by food crops.
Journal Article
Heavy metal induced oxidative stress & its possible reversal by chelation therapy.
TL;DR: A comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation is attempted, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects are attempted.
Journal ArticleDOI
Toxic Heavy Metal and Metalloid Accumulation in Crop Plants and Foods
Stephan Clemens,Jian Feng Ma +1 more
TL;DR: Proteins mediating the uptake of arsenic and cadmium have been identified, and the speciation and biotransformations of arsenic are now understood, and factors controlling the efficiency of root-to-shoot translocation and the partitioning of toxic elements through the rice node have also been identified.
References
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IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
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Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
Stephen M. Keyse,Rex M. Tyrrell +1 more
TL;DR: The observation of a high level of induction of the enzyme in cells from an organ not involved in hemoglobin breakdown strongly supports the proposal that the induction of heme oxygenase may be a general response to oxidant stress and constitutes an important cellular defense mechanism against oxidative damage.
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Cancer risks from arsenic in drinking water.
Allan H. Smith,Claudia Hopenhayn-Rich,Michael N. Bates,Helen M. Goeden,Irva Hertz-Picciotto,Heather M. Duggan,Rose Wood,Michael J. Kosnett,Martyn T. Smith +8 more
TL;DR: The evidence assessed here indicates that arsenic can also cause liver, lung, kidney, and bladder cancer and that the population cancer risks due to arsenic in U.S. water supplies may be comparable to those from environmental tobacco smoke and radon in homes.
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Cell proliferation in carcinogenesis
Samuel M. Cohen,Leon B. Ellwein +1 more
TL;DR: A biologically based, computerized description of carcinogenesis was used to show that the increase in cell proliferation can account for the carcinogenicity of nongenotoxic compounds.
Journal ArticleDOI
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.