Arsenic Exposure and Toxicology: A Historical Perspective
TLDR
The mode of action of arsenic for its disease endpoints is currently under study, and two key areas are the interaction of trivalent arsenicals with sulfur in proteins and the ability of arsenic to generate oxidative stress.About:
This article is published in Toxicological Sciences.The article was published on 2011-10-01 and is currently open access. It has received 1007 citations till now. The article focuses on the topics: Arsenic & Arsenic poisoning.read more
Citations
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Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants
TL;DR: A deep understanding of the mechanisms involved in eliciting heavy metals toxicity is provided in order to highlight the necessity for development of strategies to decrease exposure to these metals, as well as to identify substances that contribute significantly to overcome their hazardous effects within the body of living organisms.
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A review on detection of heavy metal ions in water – An electrochemical approach
Manju Bhargavi Gumpu,Swaminathan Sethuraman,Uma Maheswari Krishnan,John Bosco Balaguru Rayappan +3 more
TL;DR: In this article, the toxicity mechanisms of various metal ions and their relationship towards the induction of oxidative stress have been summarized, and electrochemical biosensors employed in the detection of metal ions with various interfaces have been highlighted.
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Prevalence of exposure of heavy metals and their impact on health consequences
TL;DR: The global contamination of drinking water with heavy metals is discussed to assess the health hazards associated with consumption of heavy metal‐contaminated water and a relationship between exposure limits and ultimate responses produced has been reviewed.
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Arsenic binding to proteins.
TL;DR: Although the adverse health effects arising from exposure to arsenic have been well-recognized, the mechanism(s) of action responsible for the diverse range of health effects are complicated and poorly understood.
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A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.
TL;DR: In this review, the major mechanism associated with toxicities of individual metals was the generation of reactive oxygen species (ROS), and toxicities were expressed through depletion of glutathione and bonding to sulfhydryl groups of proteins.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
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Contamination of drinking-water by arsenic in Bangladesh: a public health emergency
TL;DR: The experience in Bangladesh shows that groundwater sources throughout the world that are used for drinking-water should be tested for arsenic, and the fundamental intervention is the identification and provision of arsenic-free drinking water.
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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
John Rouse,Philip Cohen,Sylviane Trigon,Michel Morange,Ana Alonso-Llamazares,Daniel Zamanillo,Tim Hunt,Angel R. Nebreda +7 more
TL;DR: The RKK, RK, and MAPKAP kinase-2 constitute a new stress-activated signal transduction pathway in vertebrates that is distinct from the classical MAPK cascade.
Arsenic in Drinking Water
TL;DR: Arsenic in drinking water: not just a problem for Bangladesh D. van Halem, S. A. Bakker, G. L. Amy, and J. C. van Dijk Delft University of Technology.
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Worldwide Occurrences of Arsenic in Ground Water
TL;DR: Nordstrom et al. as mentioned in this paper argue that human health risks from arsenic in ground water can be minimized by incorporating hydrogeochemical knowledge into water management decisions and by more careful monitoring for arsenic in geologically high-risk areas.