From the Publisher:
Written by the author of the best-selling HyperText & HyperMedia, this book provides an excellent guide to the methods of usability engineering. Special features: emphasizes cost-effective methods that will help developers improve their user interfaces immediately, shows you how to avoid the four most frequently listed reasons for delay in software projects, provides step-by-step information about which methods to use at various stages during the development life cycle, and offers information on the unique issues relating to informational usability. You do not need to have previous knowledge of usability to implement the methods provided, yet all of the latest research is covered.

Usability Engineering

世界経済・社会統計 = World development indicators

According to W. Edwards Deming, American companies require nothing less than a transformation of management style and of governmental relations with industry. In Out of the Crisis, originally published in 1982, Deming offers a theory of management based on his famous 14 Points for Management. Management's failure to plan for the future, he claims, brings about loss of market, which brings about loss of jobs. Management must be judged not only by the quarterly dividend, but by innovative plans to stay in business, protect investment, ensure future dividends, and provide more jobs through improved product and service. In simple, direct language, he explains the principles of management transformation and how to apply them.

Out of the Crisis

Purpose – The purpose of this paper is to give a state‐of‐the art overview of the Job Demands‐Resources (JD‐R) modelDesign/methodology/approach – The strengths and weaknesses of the demand‐control model and the effort‐reward imbalance model regarding their predictive value for employee well being are discussed. The paper then introduces the more flexible JD‐R model and discusses its basic premises.Findings – The paper provides an overview of the studies that have been conducted with the JD‐R model. It discusses evidence for each of the model's main propositions. The JD‐R model can be used as a tool for human resource management. A two‐stage approach can highlight the strengths and weaknesses of individuals, work groups, departments, and organizations at large.Originality/value – This paper challenges existing stress models, and focuses on both negative and positive indicators of employee well being. In addition, it outlines how the JD‐R model can be applied to a wide range of occupations, and be used to i...

The job demands-resources model : state of the art

This study focuses on burnout and its positive antipode—engagement. A model is tested in which burnout and engagement have different predictors and different possible consequences. Structural equation modeling was used to simultaneously analyze data from four independent occupational samples (total N = 1698). Results confirm the hypothesized model indicating that: (1) burnout and engagement are negatively related, sharing between 10 per cent and 25 per cent of their variances; (2) burnout is mainly predicted by job demands but also by lack of job resources, whereas engagement is exclusively predicted by available job resources; (3) burnout is related to health problems as well as to turnover intention, whereas engagement is related only to the latter; (4) burnout mediates the relationship between job demands and health problems, whereas engagement mediates the relationship between job resources and turnover intention. The fact that burnout and engagement exhibit different patterns of possible causes and consequences implies that different intervention strategies should be used when burnout is to be reduced or engagement is to be enhanced. Copyright © 2004 John Wiley & Sons, Ltd.

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Job demands, job resources, and their relationship with burnout and engagement: a multi‐sample study

Es gibt so viel zu, warum gegen evidenzbasiertes Management polemisieren?: Ein Plädoyer gegen die Bedeutungslosigkeit der Managementforschung

Depression und Umwelt: neue Beiträge zur Analyse depressionsfördernder Lebensbedingungen

A New Look at Errors

Organoids emulate many aspects of their parental tissue and have been used to study pathogen-host interactions, tissue development and regeneration, metabolic diseases, and other complex biological processes. Here, we report a robust protocol for the isolation, maintenance and differentiation of rabbit small intestinal organoids and organoid-derived cell monolayers. We also report conditions that sustain an intestinal stem cell population in spheroid culture. Rabbit intestinal spheroids and monolayer cultures propagated and expanded most efficiently in L-WRN-conditioned medium that contained the signalling factors Wnt, R-spondin and Noggin, and that had been supplemented with ROCK and TGF-β inhibitors. Organoid and monolayer differentiation was initiated by switching to a medium that contained less of the L-WRN-conditioned medium and was supplemented with ROCK and Notch signalling inhibitors. Using immunofluorescence staining and RT-qPCR, we demonstrate that organoids contained enterocytes, enteroendocrine cells, goblet cells and Paneth cells. These findings demonstrate that our rabbit intestinal organoids have many of the multi-cellular characteristics of, and closely resemble, an intestinal epithelium. This newly established organoid culture system will provide a useful tool to study rabbit gastrointestinal physiology and disease. For example, organoids and organoid-derived cells may be used to propagate and study caliciviruses and other enterotropic pathogens that cannot be grown in conventional cell culture systems.

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Isolation, culture and maintenance of rabbit intestinal organoids, and organoid-derived cell monolayers

Persistent infection with the hepatitis C virus (HCV) is a major cause of acute and chronic liver disease and frequently leads to liver cirrhosis and hepatocellular carcinoma. Current treatment is based on a combination therapy with polyethylene glycol-conjugated interferon-alpha and ribavirin, but efficacy is limited and treatment is associated with severe side-effects. More efficient and selective drugs are therefore needed. Apart from small molecule inhibitors targeting the viral key enzymes, especially the NS3 proteinase and the NS5B RNA-dependent RNA polymerase, nucleic acid (NA)-based antiviral intervention is an attractive option. Originally, antisense oligo- nucleotides and ribozymes targeting highly conserved regions in the HCV genome have been developed. More recently, short interfering RNAs (siRNAs) were shown to potently block HCV RNA replication in cell culture. However, the high degree of sequence diversity between different HCV genotypes, the rapid evolution of quasispecies and the delivery of antivirally active NAs are challenging problems of NA-based therapies. Here, we will review the current state of NA-based approaches designed to interfere with HCV replication.

Michael Frese

Papers

Es gibt so viel zu, warum gegen evidenzbasiertes Management polemisieren?: Ein Plädoyer gegen die Bedeutungslosigkeit der Managementforschung

Depression und Umwelt: neue Beiträge zur Analyse depressionsfördernder Lebensbedingungen

A New Look at Errors

Isolation, culture and maintenance of rabbit intestinal organoids, and organoid-derived cell monolayers

Inhibition of hepatitis C virus by nucleic acid-based antiviral approaches