M
Michael I. Trenell
Researcher at Newcastle University
Publications - 167
Citations - 10868
Michael I. Trenell is an academic researcher from Newcastle University. The author has contributed to research in topics: Fatty liver & Randomized controlled trial. The author has an hindex of 46, co-authored 162 publications receiving 8342 citations. Previous affiliations of Michael I. Trenell include Leeds General Infirmary & University of Sydney.
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Journal ArticleDOI
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Renae J. Stefanetti,Michael I. Trenell,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Naveed Sattar,Roy Taylor +24 more
TL;DR: The findings show that, at 12 months, almost half of participants achieved remission to a non-diabetic state and off antidiabetic medications, from baseline to 12 months.
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Treatment of NAFLD with diet, physical activity and exercise
TL;DR: Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH and should be accompanied by the implementation of strategies to avoid relapse and weight regain.
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Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study.
Aiden R. Doherty,Dan Jackson,Nils Y. Hammerla,Thomas Plötz,Patrick Olivier,Malcolm H. Granat,Thomas E. White,Vincent T. van Hees,Michael I. Trenell,Christoper G. Owen,Stephen J. Preece,Rob Gillions,S.M. Sheard,Tim Peakman,Soren Brage,Nicholas J. Wareham +15 more
TL;DR: The summary measure of overall physical activity is lower in older participants and age-related differences in activity are most prominent in the afternoon and evening, which lays the foundation for studies of physical activity and its health consequences.
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Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
David van der Poorten,Kerry-Lee Milner,Jason M. Hui,Alexander Hodge,Michael I. Trenell,James G. Kench,Roslyn M. London,Tony Peduto,Donald J. Chisholm,Jacob George +9 more
TL;DR: Visceral fat is directly associated with liver inflammation and fibrosis independent of insulin resistance and hepatic steatosis and should be a central target for future interventions in nonalcoholic steatohepatitis and indeed all metabolic disease.
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Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review.
TL;DR: Lifestyle modifications leading to weight reduction and/or increased physical activity consistently reduced liver fat and improved glucose control/insulin sensitivity and limited data suggest that lifestyle interventions may hold benefits for histopathology.