Michael J. Cooke

TL;DR: In vivo transplantation studies in mice showed that RSPCs delivered in HAMC were more evenly distributed in the sub-retinal space than those delivered in traditional saline solutions, suggesting that HAMC is a promising vehicle for cellular delivery to the degenerating retina overcoming previously reported barriers to tissue integration in the retina.

TL;DR: Analysis of arrested embryos demonstrated that these embryos express pluripotency marker genes such OCT4, NANOG, and REX1, which demonstrate that arrested embryos are additional valuable resources to surplus and donated developing embryos and should be used to study early human development or derive pluripotent hESC.

TL;DR: It is shown that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components through C-terminal region binds to the regulatory regions of CDK6 and CDC25A genes under normal physiological conditions.

TL;DR: The proposed injectable and bioresorbable hydrogel blend of hyaluronan and methylcellulose (HAMC) improves cell survival and integration of retinal stem cell-derived rods in the retina and improves cell transplantation efficacy in two CNS models, suggesting broad applicability.

TL;DR: Erythropoietin delivered from HAMC at 4 and 11 days post-stroke resulted in attenuated inflammatory response, reduced stroke cavity size, increased number of both neurons in the peri-infarct region and migratory neuroblasts in the subventricular zone, and decreased apoptosis in both the subventionricular zone and the injured cortex.