Lyle Armstrong

TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.

TL;DR: An overview of the most important ethical issues in stem cell therapy is provided, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine.

TL;DR: Bioinformatic analysis of expression changes observed when these cells were induced to differentiate as embryoid bodies suggested that quite a few of the downregulated genes were components of signal transduction networks and implicated components of the PI3K/AKT kinase, MAPK/ERK and NFkappabeta pathways and confirmed that these components are decreased upon differentiation.

TL;DR: The findings suggest that NANOG acts as a gatekeeper of pluripotency in human embryonic stem and carcinoma cells by preventing their differentiation to extraembryonic endoderm and trophectoderm lineages.

TL;DR: Investigation of coculture with monolayers of cells derived from mouse AGM and fetal liver, or with stromal cell lines derived from these tissues, found that under such conditions hESC-derived differentiating cells formed early hematopoietic progenitors, with a peak at day 18-21 of differentiation that corresponded to the highest CD34 expression.