G
George Anyfantis
Researcher at Centre for Life
Publications - 9
Citations - 1054
George Anyfantis is an academic researcher from Centre for Life. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 9 publications receiving 961 citations. Previous affiliations of George Anyfantis include Newcastle upon Tyne Hospitals NHS Foundation Trust & Newcastle University.
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Journal ArticleDOI
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
Katherine Amps,Peter W. Andrews,George Anyfantis,Lyle Armstrong,Stuart Avery,Hossein Baharvand,Julie C. Baker,Duncan Baker,Maria D. Barbadillo Muñoz,Stephen J. Beil,Nissim Benvenisty,Dalit Ben-Yosef,Juan Carlos Biancotti,Alexis Bosman,Romulo M. Brena,Daniel R. Brison,Gunilla Caisander,Marãa V. Camarasa,Jieming Chen,Eric Chiao,Young Min Choi,Andre Choo,D.M. Collins,Alan Colman,Jeremy M. Crook,George Q. Daley,Anne Dalton,Paul A. De Sousa,Chris Denning,J.M. Downie,Petr Dvorak,Karen Dyer Montgomery,Anis Feki,Angela Ford,Victoria Fox,Ana Maria Fraga,Tzvia Frumkin,Lin Ge,Paul J. Gokhale,Tamar Golan-Lev,Hamid Gourabi,Michal Gropp,Lu GuangXiu,Aleš Hampl,Katie Harron,Lyn Healy,Wishva Herath,Frida Holm,Outi Hovatta,Johan Hyllner,Maneesha S. Inamdar,Astrid K. Irwanto,Tetsuya Ishii,Marisa Jaconi,Ying Jin,Susan J. Kimber,Sergey Kiselev,Barbara B. Knowles,Oded Kopper,Valeri Kukharenko,Anver Kuliev,Maria A. Lagarkova,Peter W. Laird,Majlinda Lako,Andrew L. Laslett,Neta Lavon,Dong Ryul Lee,Jeoung Eun Lee,Chunliang Li,Linda S. Lim,Tenneille Ludwig,Yu Ma,Edna Maltby,Ileana Mateizel,Yoav Mayshar,Maria Mileikovsky,Stephen L. Minger,Takamichi Miyazaki,Shin Yong Moon,Harry Moore,Christine L. Mummery,Andras Nagy,Norio Nakatsuji,Kavita Narwani,Steve Oh,Sun Kyung Oh,Cia Olson,Timo Otonkoski,Fei Pan,In-Hyun Park,Steve Pells,Martin F. Pera,Lygia da Veiga Pereira,Ouyang Qi,Grace Selva Raj,Benjamin Reubinoff,Alan Robins,Paul Robson,Janet Rossant,Ghasem Hosseini Salekdeh,Thomas C. Schulz,Karen Sermon,Jameelah Sheik Mohamed,Hui Shen,Eric S Sherrer,Kuldip S. Sidhu,Shirani Sivarajah,Heli Skottman,Claudia Spits,Glyn Stacey,Raimund Strehl,Nick Strelchenko,Hirofumi Suemori,Bowen Sun,Riitta Suuronen,Kazutoshi Takahashi,Timo Tuuri,Parvathy Venu,Yuri Verlinsky,Dorien Ward-van Oostwaard,Daniel J. Weisenberger,Yue Wu,Shinya Yamanaka,Lorraine E. Young,Qi Zhou +124 more
TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.
Journal ArticleDOI
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A
Xin Zhang,Irina Neganova,Stefan Przyborski,Chunbo Yang,Michael J. Cooke,Stuart P. Atkinson,George Anyfantis,Stefan Fenyk,W. Nicol Keith,S F Hoare,Owen Hughes,Tom Strachan,Miodrag Stojkovic,Philip W. Hinds,Lyle Armstrong,Majlinda Lako +15 more
TL;DR: It is shown that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components through C-terminal region binds to the regulatory regions of CDK6 and CDC25A genes under normal physiological conditions.
Journal ArticleDOI
A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation.
Chunbo Yang,Stefan Przyborski,Stefan Przyborski,Michael J. Cooke,Michael J. Cooke,Xin Zhang,Rebecca Stewart,George Anyfantis,Stuart P. Atkinson,Gabriele Saretzki,Lyle Armstrong,Majlinda Lako +11 more
TL;DR: Modulated the expression of TERT indicated for the first time an important role for TERT in the maintenance of human ESC pluripotency, cell cycle regulation, and in vitro differentiation capacity.
Journal ArticleDOI
Putative Role of Hyaluronan and Its Related Genes, HAS2 and RHAMM, in Human Early Preimplantation Embryogenesis and Embryonic Stem Cell Characterization
Meenakshi Choudhary,Xin Zhang,Petra Stojkovic,Louise Hyslop,George Anyfantis,Mary Herbert,Alison Murdoch,Miodrag Stojkovic,Majlinda Lako +8 more
TL;DR: It is shown for the first time that HA synthase gene HAS2 and its binding receptor RHAMM are differentially expressed during all stages of preimplantation human embryos and hESC, highlighting an important role for RhamM in maintenance of hESc pluripotency, viability, and cell cycle control.
Journal ArticleDOI
An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure
Dean Hallam,Joseph Collin,Sanja Bojic,Valeria Chichagova,Adriana Buskin,Yaobo Xu,Lucia Lafage,Elsje G. Otten,George Anyfantis,Carla B. Mellough,Stefan Przyborski,Sameer E. Al-Harthi,Viktor I. Korolchuk,Andrew J. Lotery,Gabriele Saretzki,Martin McKibbin,Lyle Armstrong,David H. W. Steel,David J. Kavanagh,Majlinda Lako +19 more
TL;DR: The data indicate that the patient specific iPSC model provides a robust platform for understanding the role of complement activation in AMD, evaluating new therapies based on complement modulation and drug testing and generating RPE cells that show local secretion of several proteins involved in the complement pathway.