M
Michael J. Hynes
Researcher at National University of Ireland, Galway
Publications - 266
Citations - 11221
Michael J. Hynes is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Aspergillus nidulans & Gene. The author has an hindex of 55, co-authored 265 publications receiving 10695 citations. Previous affiliations of Michael J. Hynes include University of Melbourne & National University of Ireland.
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Regulation of Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDDH) in Aspergillus nidulans
TL;DR: The current hypothesis is that alcA and aldA are the structural genes for ADH and AldDH respectively and alcR is a transacting regulatory gene coding for a protein whose function is necessary for the expression of the alc a and a AldA genes.
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Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans
TL;DR: A model for amdR-mediated regulation of gene expression in which the low constitutive level of amdR product sets the upper limits of basal and induced transcription of the structural genes is formed was formed by showing that multiple copies of the amdR gene can reverse this phenomenon (antititration).
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Genetic Analysis of the Role of Peroxisomes in the Utilization of Acetate and Fatty Acids in Aspergillus nidulans
TL;DR: The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of β-oxidation enzymes, and mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxISomal localization.
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Control of morphogenesis and actin localization by the Penicillium marneffei RAC homolog.
TL;DR: The cloning and functional characterization of a RAC homolog, cflB, from the dimorphic fungus Penicillium marneffei, shows that these two GTPases have both overlapping and distinct roles during growth and development.
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The Ras and Rho GTPases genetically interact to co‐ordinately regulate cell polarity during development in Penicillium marneffei
TL;DR: It is shown that RasA (Ras) acts upstream of CflA (Cdc42) to regulate germination of spores and polarized growth of both hyphal and yeast cells, while also exhibiting CFlA‐independent activities.