M
Michael J. Lodes
Researcher at CombiMatrix
Publications - 75
Citations - 3997
Michael J. Lodes is an academic researcher from CombiMatrix. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 32, co-authored 75 publications receiving 3873 citations. Previous affiliations of Michael J. Lodes include GlaxoSmithKline & Corixa Corporation.
Papers
More filters
Journal ArticleDOI
Bacterial flagellin is a dominant antigen in Crohn disease
Michael J. Lodes,Yingzi Cong,Charles O. Elson,Raodoh Mohamath,Carol J. Landers,Stephan R. Targan,Madeline Fort,Robert M. Hershberg,Robert M. Hershberg +8 more
TL;DR: Serological expression cloning was used to identify commensal bacterial proteins that could contribute to the pathogenesis of IBD and identify flagellins as a class of immunodominant antigens that stimulate pathogenic intestinal immune reactions in genetically diverse hosts.
Journal ArticleDOI
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.
Stephan R. Targan,Carol J. Landers,Huiying Yang,Michael J. Lodes,Michael J. Lodes,Yingzi Cong,Yingzi Cong,Konstantinos A. Papadakis,Eric A. Vasiliauskas,Charles O. Elson,Charles O. Elson,Robert M. Hershberg,Robert M. Hershberg +12 more
TL;DR: Serum responses to CBir1 independently identify a unique subset of patients with complicated CD patients, and this bacterial antigen was identified in a murine model and has a similar pattern of aberrant reactivity in a subset of CD patients.
Journal ArticleDOI
Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray
Michael J. Lodes,Marcelo Caraballo,Dominic Suciu,Sandra B. Munro,Amit Kumar,Brooke P. Anderson +5 more
TL;DR: It is shown that sufficient miRNAs are present in one milliliter of serum to detect miRNA expression patterns, without the need for amplification techniques, and that these expression patterns are able to correctly discriminate between normal and cancer patient samples.
Journal ArticleDOI
Propionibacterium acnes Types I and II Represent Phylogenetically Distinct Groups
Andrew McDowell,Susanna Valanne,Gordon Ramage,Michael M. Tunney,J. V. Glenn,G. C. McLorinan,Ajay Bhatia,Jean Francois Maisonneuve,Michael J. Lodes,David H. Persing,Sheila Patrick +10 more
TL;DR: The study demonstrates that the phenotypic differences between P. acnes types I and II reflect deeper differences in their phylogeny, and nucleotide sequencing provides an accurate method for identifying the type status of P. Acnes isolates.
Journal ArticleDOI
CombiMatrix oligonucleotide arrays: genotyping and gene expression assays employing electrochemical detection.
Andrey L. Ghindilis,Maria W. Smith,Kevin R. Schwarzkopf,Kristian M. Roth,Kia Peyvan,Sandra B. Munro,Michael J. Lodes,Axel G. Stöver,Karen Bernards,Kilian Dill,Andy McShea +10 more
TL;DR: The ElectraSense platform has been used to develop nucleic acid assays for highly accurate genotyping of a variety of pathogens including bio-threat agents and common pathogens of the respiratory tract.