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Robert M. Hershberg
Researcher at Celgene
Publications - 68
Citations - 5701
Robert M. Hershberg is an academic researcher from Celgene. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 31, co-authored 68 publications receiving 5192 citations. Previous affiliations of Robert M. Hershberg include University of California, Los Angeles & Infectious Disease Research Institute.
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Journal ArticleDOI
Bacterial flagellin is a dominant antigen in Crohn disease
Michael J. Lodes,Yingzi Cong,Charles O. Elson,Raodoh Mohamath,Carol J. Landers,Stephan R. Targan,Madeline Fort,Robert M. Hershberg,Robert M. Hershberg +8 more
TL;DR: Serological expression cloning was used to identify commensal bacterial proteins that could contribute to the pathogenesis of IBD and identify flagellins as a class of immunodominant antigens that stimulate pathogenic intestinal immune reactions in genetically diverse hosts.
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Intestinal epithelial cells secrete exosome–like vesicles
Guillaume van Niel,Graça Raposo,Céline Candalh,Muriel Boussac,Robert M. Hershberg,Nadine Cerf–Bensussan,Martine Heyman +6 more
TL;DR: Human IEC lines secrete exosomes bearing accessory molecules that may be involved in antigen presentation consistent with a model in which IECs may influence antigen presentation in the mucosal or systemic immune system independent of direct cellular contact with effector cells.
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Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.
Stephan R. Targan,Carol J. Landers,Huiying Yang,Michael J. Lodes,Michael J. Lodes,Yingzi Cong,Yingzi Cong,Konstantinos A. Papadakis,Eric A. Vasiliauskas,Charles O. Elson,Charles O. Elson,Robert M. Hershberg,Robert M. Hershberg +12 more
TL;DR: Serum responses to CBir1 independently identify a unique subset of patients with complicated CD patients, and this bacterial antigen was identified in a murine model and has a similar pattern of aberrant reactivity in a subset of CD patients.
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Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia
Glenn T. Furuta,Jerrold R. Turner,Cormac T. Taylor,Robert M. Hershberg,Katrina M. Comerford,Sailaja Narravula,Daniel K. Podolsky,Sean P. Colgan +7 more
TL;DR: HIF-1–dependent induction of ITF may provide an adaptive link for maintenance of barrier function during hypoxia, and help to protect epithelial barrier during episodes of intestinalHypoxia-elicited increases in intestinal permeability in ITF null mice are revealed.
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Antigen processing and presentation by intestinal epithelial cells – polarity and complexity
Robert M. Hershberg,Lloyd Mayer +1 more
TL;DR: The evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa is discussed.