M
Michael L. Cunningham
Researcher at Research Triangle Park
Publications - 12
Citations - 829
Michael L. Cunningham is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Gene expression & Peroxisome proliferator-activated receptor. The author has an hindex of 10, co-authored 12 publications receiving 786 citations. Previous affiliations of Michael L. Cunningham include National Institutes of Health & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate ☆
Robert J. Kavlock,Kim Boekelheide,Robert E. Chapin,Michael L. Cunningham,Elaine M. Faustman,Paul M. D. Foster,Mari S. Golub,Rogene F. Henderson,Irwin Hinberg,Ruth Little,Jennifer Seed,Katherine M. Shea,Sonia Tabacova,Rochelle W. Tyl,Paige L. Williams,Timothy R. Zacharewski +15 more
TL;DR: This poster presents a probabilistic procedure to evaluate the phytochemical properties of anthrax, and the results have shown to be safe and beneficial for human health and the environment.
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Phenotypic Anchoring of Acetaminophen-Induced Oxidative Stress with Gene Expression Profiles in Rat Liver
Christine L. Powell,Oksana Kosyk,Pamela K. Ross,Robert Schoonhoven,Gunnar Boysen,James A. Swenberg,Alexandra N. Heinloth,Gary A. Boorman,Michael L. Cunningham,Michael L. Cunningham,Richard S. Paules,Ivan Rusyn +11 more
TL;DR: The accumulation of nitrotyrosine and 8-OH-dG adducts along with reduced GSH content in the liver phenotypically anchors the oxidative stress gene expression signature observed with a subtoxic dose of APAP, lending support to the validity of gene expression studies as a sensitive and biologically meaningful end point in toxicology.
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Comparison of Dose–Response Relationships for Induction of Lipid Metabolizing and Growth Regulatory Genes by Peroxisome Proliferators in Rat Liver☆☆☆
Martha A. Belury,Silvia Y. Moya-Camarena,Hong Sun,Erica Snyder,John W. Davis,Michael L. Cunningham,John P. Vanden Heuvel +6 more
TL;DR: This study shows the complexity of responses mediated by peroxisome proliferators, with ACO being a good marker of PPAR-mediated events as well as cell proliferation, while c-myc, a known growth regulatory gene, was induced by Wy14,643 partially via PPAR but did not correlate well with cell proliferation.
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Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the λcII locus in Big Blue® transgenic mice
TL;DR: It is suggested that the cII locus is less sensitive than the lacI locus to mutation induction by non-DNA reactive carcinogens in B6C3F1 mice.
Journal ArticleDOI
Time-course comparison of xenobiotic activators of CAR and PPARα in mouse liver
Pamela K. Ross,Courtney G. Woods,Courtney G. Woods,Blair U. Bradford,Oksana Kosyk,Daniel M. Gatti,Michael L. Cunningham,Ivan Rusyn +7 more
TL;DR: Common gene expression fingerprints of exposure to activators of CAR and PPARalpha in rodent liver are established and it is demonstrated that despite similar phenotypic changes, molecular pathways differ between classes of chemical carcinogens.