M
Michaël Porcu
Researcher at Katholieke Universiteit Leuven
Publications - 15
Citations - 1037
Michaël Porcu is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Neuroblastoma & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 10, co-authored 15 publications receiving 904 citations.
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Journal ArticleDOI
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
Kim De Keersmaecker,Zeynep Kalender Atak,Ning Li,Carmen Vicente,Stephanie Patchett,Tiziana Girardi,Valentina Gianfelici,Ellen Geerdens,Emmanuelle Clappier,Michaël Porcu,Idoya Lahortiga,Rossella Luca,Jiekun Yan,Gert Hulselmans,Hilde Vranckx,Roel Vandepoel,Bram Sweron,Kris Jacobs,Nicole Mentens,Iwona Wlodarska,Barbara Cauwelier,Jacqueline Cloos,Jean Soulier,Anne Uyttebroeck,Claudia Bagni,Bassem A. Hassan,Peter Vandenberghe,Arlen W. Johnson,Stein Aerts,Jan Cools +29 more
TL;DR: Exome sequencing on 67 T-ALLs is used to gain insight into the mutational spectrum in these leukemias and identify the ribosome as a potential oncogenic factor.
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Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Sara De Brouwer,Katleen De Preter,Candy Kumps,Piotr Zabrocki,Michaël Porcu,Ellen M. Westerhout,Arjan Lakeman,Jo Vandesompele,Jasmien Hoebeeck,Tom Van Maerken,Anne De Paepe,Genevieve Laureys,Johannes H. Schulte,Alexander Schramm,Caroline Van den Broecke,Joëlle Vermeulen,Nadine Van Roy,Klaus Beiske,Marleen Renard,Rosa Noguera,Olivier Delattre,Isabelle Janoueix-Lerosey,Per Kogner,Tommy Martinsson,Akira Nakagawara,Miki Ohira,Huib N. Caron,Angelika Eggert,Jan Cools,Rogier Versteeg,Frank Speleman +30 more
TL;DR: A meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression found Chromosome 2p gains were associated with a significantly increased ALK expression, which was also correlated with poor survival.
Journal ArticleDOI
Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia
Michaël Porcu,Maria Kleppe,Valentina Gianfelici,Ellen Geerdens,Kim De Keersmaecker,Marco Tartaglia,Robin Foà,Jean Soulier,Barbara Cauwelier,Anne Uyttebroeck,Elizabeth Macintyre,Peter Vandenberghe,Vahid Asnafi,Jan Cools +13 more
TL;DR: It is demonstrated that down-regulation of CD45 expression sensitizes T cells to cytokine stimulation, as observed by increased JAK/STAT signaling, whereas overexpression of CD43 decreases cytokine-induced signaling, and identifies a tumor suppressor role for CD45 in T-cell acute lymphoblastic leukemia.
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High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes
Zeynep Kalender Atak,Kim De Keersmaecker,Valentina Gianfelici,Ellen Geerdens,Roel Vandepoel,Daphnie Pauwels,Michaël Porcu,Idoya Lahortiga,Vanessa Brys,Willy G. Dirks,Hilmar Quentmeier,Jacqueline Cloos,Harry Cuppens,Anne Uyttebroeck,Peter Vandenberghe,Jan Cools,Stein Aerts +16 more
TL;DR: An optimized analysis pipeline for Roche/454 data is established that can be applied to accurately detect gene mutations in cancer, which led to the identification of several new candidate T-ALL driver mutations.
Journal ArticleDOI
Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment
Irina Lambertz,Candy Kumps,Shana Claeys,Sven Lindner,Anneleen Beckers,Els Janssens,Daniel R. Carter,Alex Cazes,Belamy B. Cheung,Marilena De Mariano,An De Bondt,Sara De Brouwer,Olivier Delattre,Jay Gibbons,Isabelle Janoueix-Lerosey,Genevieve Laureys,Chris Liang,Glenn M. Marchall,Michaël Porcu,Junko Takita,David Camacho Trujillo,Ilse Van den Wyngaert,Nadine Van Roy,Alan Van Goethem,Tom Van Maerken,Piotr Zabrocki,Jan Cools,Johannes H. Schulte,Jorge Vialard,Frank Speleman,Katleen De Preter +30 more
TL;DR: In this paper, a 77-gene ALK signature was established and successfully validated in primary neuroblastoma samples, using ALKF1174L and ALKR1275Q regulable overexpression constructs and in other ALKomas.