T
Tommy Martinsson
Researcher at University of Gothenburg
Publications - 193
Citations - 8677
Tommy Martinsson is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 53, co-authored 186 publications receiving 7992 citations. Previous affiliations of Tommy Martinsson include Lund University & Sahlgrenska University Hospital.
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Journal ArticleDOI
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.
Gaurav Kumar Pandey,Sanhita Mitra,Santhilal Subhash,Falk Hertwig,Meena Kanduri,Kankadeb Mishra,Susanne Fransson,Abiarchana Ganeshram,Tanmoy Mondal,Sashidhar Bandaru,Malin Östensson,Levent M. Akyürek,Jonas Abrahamsson,Susan Pfeifer,Erik Larsson,Leming Shi,Zhiyu Peng,Matthias Fischer,Tommy Martinsson,Fredrik Hedborg,Per Kogner,Chandrasekhar Kanduri +21 more
TL;DR: NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST, and contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
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High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours.
TL;DR: The results of the present study support that the ALK protein contributes to NB oncogenesis providing a highly interesting putative therapeutic target in a subset of unfavourable NB tumours.
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Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Sara De Brouwer,Katleen De Preter,Candy Kumps,Piotr Zabrocki,Michaël Porcu,Ellen M. Westerhout,Arjan Lakeman,Jo Vandesompele,Jasmien Hoebeeck,Tom Van Maerken,Anne De Paepe,Genevieve Laureys,Johannes H. Schulte,Alexander Schramm,Caroline Van den Broecke,Joëlle Vermeulen,Nadine Van Roy,Klaus Beiske,Marleen Renard,Rosa Noguera,Olivier Delattre,Isabelle Janoueix-Lerosey,Per Kogner,Tommy Martinsson,Akira Nakagawara,Miki Ohira,Huib N. Caron,Angelika Eggert,Jan Cools,Rogier Versteeg,Frank Speleman +30 more
TL;DR: A meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression found Chromosome 2p gains were associated with a significantly increased ALK expression, which was also correlated with poor survival.
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Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations.
J. Björk,Helena I. Åkerbrant,Lennart Iselius,Annika Bergman,Yvonne Engwall,Jan Wahlström,Tommy Martinsson,Margareta Nordling,Rolf Hultcrantz +8 more
TL;DR: The life time risk of severe periampullary lesions in FAP patients is high, and an association between stage IV periampsullary adenomas and a malignant course of the periAMPullaryAdenomatosis is strongly suggestive.
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High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset
Helena Carén,Hanna Kryh,Maria Nethander,Rose-Marie Sjöberg,Catarina Träger,Staffan Nilsson,Jonas Abrahamsson,Per Kogner,Tommy Martinsson +8 more
TL;DR: In the groups with segmental aberrations without MNA or 11q deletion, the tumors with 17q gain have worse prognosis than those with segmentals without 17Q gain, which have a favorable outcome, and this study stresses that genome-wide microarray analyses should be included in clinical management.