M
Michael R. Green
Researcher at University of Texas MD Anderson Cancer Center
Publications - 597
Citations - 65007
Michael R. Green is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: RNA splicing & RNA. The author has an hindex of 126, co-authored 537 publications receiving 57447 citations. Previous affiliations of Michael R. Green include Eppley Institute for Research in Cancer and Allied Diseases & United States University.
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Journal ArticleDOI
Robust enumeration of cell subsets from tissue expression profiles
Aaron M. Newman,Chih Long Liu,Michael R. Green,Andrew J. Gentles,Weiguo Feng,Yue Xu,Chuong D. Hoang,Maximilian Diehn,Arash Ash Alizadeh +8 more
TL;DR: CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types when applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors.
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Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
TL;DR: In this paper, a simple and efficient method for synthesizing pure single stranded RNAs of virtually any structure is described, based on the unusually specific RNA synthesis by bacteriophage SP6 RNA polymerase which initiates transcription exclusively at an SP6 promoter.
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Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
Michael R. Green,Stefano Monti,Scott J. Rodig,Przemyslaw Juszczynski,Treeve Currie,Evan O'Donnell,Bjoern Chapuy,Kunihiko Takeyama,Donna Neuberg,Todd R. Golub,Jeffery L. Kutok,Margaret A. Shipp +11 more
TL;DR: High-resolution copy number data with transcriptional profiles are integrated and identified the immunoregulatory genes, PD-L1 andPD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets.
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Transcriptional Regulatory Elements in the Human Genome
TL;DR: The methods currently used to identify transcriptional regulatory elements are discussed, and the ability of these methods to be scaled up for the purpose of annotating the entire human genome is discussed.