Yue Xu

TL;DR: CIBERSORT outperformed other methods with respect to noise, unknown mixture content and closely related cell types when applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen and fixed tissues, including solid tumors.

TL;DR: A pan-cancer resource and meta-analysis of expression signatures from ∼18,000 human tumors with overall survival outcomes across 39 malignancies is presented and it is found that expression of favorably prognostic genes, including KLRB1 (encoding CD161), largely reflect tumor-associated leukocytes.

TL;DR: This radiogenomics strategy for identifying imaging biomarkers may enable a more rapid evaluation of novel imaging modalities, thereby accelerating their translation to personalized medicine.

TL;DR: The role of Notch3 in tumor propagation may provide a therapeutic target for NSCLC and the TPC population is enriched after chemotherapy, and the gene signature of mouse TPCs correlates with poor prognosis in humanNSCLC.

TL;DR: PTK7 is defined as a highly and specifically expressed gene in adenocarcinoma and a potential therapeutic target in this subset of non-small cell lung cancer (NSCLC); and RNA interference-mediated attenuation of PTK7 decreased cell viability and increased apoptosis in a subset of adenoplastoma cell lines.