M
Michael R. Horsman
Researcher at Aarhus University Hospital
Publications - 256
Citations - 11471
Michael R. Horsman is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Hypoxia (medical) & Tumor hypoxia. The author has an hindex of 57, co-authored 253 publications receiving 10628 citations. Previous affiliations of Michael R. Horsman include Aarhus University & Lincoln's Inn.
Papers
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Journal ArticleDOI
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Martin O. Leach,Kevin M. Brindle,Jeffrey L. Evelhoch,John R. Griffiths,Michael R. Horsman,Alan Jackson,Gordon C Jayson,Ian Judson,Michael V. Knopp,R. J. Maxwell,D McIntyre,Anwar R. Padhani,Patricia M Price,R Rathbone,Gordon J. S. Rustin,Paul S. Tofts,Gillian M. Tozer,W Vennart,John C. Waterton,Stephen R. Williams,Paul Workman +20 more
TL;DR: The outcome of a workshop that considered the methodology and design of magnetic resonance studies is reported, recommending how this new tool might best be used.
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Imaging hypoxia to improve radiotherapy outcome
TL;DR: The potential use of imaging to help improve clinical outcome to radiotherapy is critically assessed to identify those patients on an individual basis who have hypoxic tumours and, thus, at the very least should receive some form of hypoxic modifier in conjunction with radiotherapy.
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Modification of Hypoxia-Induced Radioresistance in Tumors by the Use of Oxygen and Sensitizers.
TL;DR: The overall results showed that the biological issue related to hypoxia appears to be a sound rationale, which may impact the outcome of radiotherapy, especially with head and neck carcinoma.
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Hyperthermia: a potent enhancer of radiotherapy.
TL;DR: There are a number of large randomised clinical trials that clearly show the potential of hyperthermia to significantly improve both local tumour control and survival after radiation therapy, without a significant increase in side-effects.
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Vascular‐targeting therapies for treatment of malignant disease
TL;DR: The goal of these approaches is to induce a rapid and catastrophic shutdown of the vascular function of the tumor so that blood flow is arrested and tumor cell death due to the resulting oxygen and nutrient deprivation and buildup of waste products occurs.