M
Michael Reich
Researcher at University of California, San Diego
Publications - 12
Citations - 7113
Michael Reich is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Software & Workflow. The author has an hindex of 6, co-authored 10 publications receiving 6384 citations. Previous affiliations of Michael Reich include Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
Justin Lamb,Emily D. Crawford,David Peck,Joshua W. Modell,Irene C. Blat,Matthew J. Wrobel,Jim Lerner,Jean Philippe Brunet,Aravind Subramanian,Kenneth N. Ross,Michael Reich,Haley Hieronymus,Haley Hieronymus,Guo Wei,Guo Wei,Scott A. Armstrong,Scott A. Armstrong,Stephen J. Haggarty,Stephen J. Haggarty,Paul A. Clemons,Ru Wei,Steven A. Carr,Eric S. Lander,Eric S. Lander,Todd R. Golub +24 more
TL;DR: The first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules is created, and it is demonstrated that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.
Journal ArticleDOI
Multiclass cancer diagnosis using tumor gene expression signatures
Sridhar Ramaswamy,Pablo Tamayo,Ryan Rifkin,Sayan Mukherjee,Chen-Hsiang Yeang,Michael Angelo,Christine Ladd,Michael Reich,Eva Latulippe,Jill P. Mesirov,Tomaso Poggio,William L. Gerald,Massimo Loda,Eric S. Lander,Todd R. Golub,Todd R. Golub +15 more
TL;DR: The results demonstrate the feasibility of accurate, multiclass molecular cancer classification and suggest a strategy for future clinical implementation of molecular cancer diagnostics.
Journal ArticleDOI
Molecular classification of multiple tumor types.
Chen-Hsiang Yeang,Sridhar Ramaswamy,Pablo Tamayo,Sayan Mukherjee,Ryan Rifkin,Michael Angelo,Michael Reich,Eric S. Lander,Jill P. Mesirov,Todd R. Golub +9 more
TL;DR: This work obtained 190 samples from 14 tumor classes and generated a combined expression dataset containing 16063 genes for each of those samples, and performed multi-class classification by combining the outputs of binary classifiers.
Journal ArticleDOI
Cytoscape: the network visualization tool for GenomeSpace workflows.
Barry Demchak,Tim Hull,Michael Reich,Ted Liefeld,Michael E. Smoot,Trey Ideker,Jill P. Mesirov +6 more
TL;DR: This paper presents the design and operation of the Cytoscape GenomeSpace app, which accomplishes this integration, thereby providing critical analysis and visualization functionality for Genome Space users.
Journal ArticleDOI
GeneCluster 2.0: an advanced toolset for bioarray analysis
TL;DR: GeneCluster 2.0 greatly expands the data analysis capabilities of GeneCluster 1.0 by adding classification, class discovery and permutation test methods.