Irene C. Blat

TL;DR: The first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules is created, and it is demonstrated that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.

TL;DR: Three-colour single-molecule fluorescent in situ hybridization is applied to study a comprehensive panel of intestinal stem-cell markers during homeostasis, ageing and regeneration and finds that the expression of all markers overlaps at crypt-base cells.

TL;DR: In this paper, a three-colour single-molecule fluorescent in situ hybridization is used to show overlapping expression of intestinal stem-cell markers during homeostasis, ageing and regeneration.

TL;DR: In this paper, the authors investigated the design principles governing the dynamics of these proportions during crypt morphogenesis and showed that a proliferation strategy known as a ''bang-bang'' control minimizes the time to obtain a mature crypt.

TL;DR: It is shown that a proliferation strategy known as a "bang-bang" control minimizes the time to obtain a mature crypt, and the approach can be used to uncover similar design principles in other developmental systems.