Ru Wei

TL;DR: The first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules is created, and it is demonstrated that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.

TL;DR: It is demonstrated that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo.

TL;DR: A mass spectrometry‐based strategy to simultaneously measure 191 metabolites following glucose ingestion laid the groundwork for using metabolic profiling to define an individual's ‘insulin response profile’, which could have value in predicting diabetes, its complications, and in guiding therapy.

TL;DR: A role for metabolic profiling is identified in the early detection of myocardial injury and it is suggested that similar approaches may be used for detection or prediction of other disease states.