M
Michael S. Finnin
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 6
Citations - 2829
Michael S. Finnin is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone deacetylase & Crystal structure. The author has an hindex of 5, co-authored 6 publications receiving 2727 citations. Previous affiliations of Michael S. Finnin include Columbia University.
Papers
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Journal ArticleDOI
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Michael S. Finnin,Jill R. Donigian,Alona Cohen,Victoria M. Richon,Richard A. Rifkind,Paul A. Marks,Ronald Breslow,Nikola P. Pavletich +7 more
TL;DR: The structure of the histone deacetylase catalytic core is described, as revealed by the crystal structure of a homologue from the hyperthermophilic bacterium Aquifex aeolicus, and it is established that the residues that make up the active site and contact the inhibitors are conserved across the HDAC family.
Journal ArticleDOI
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Brenda A. Schulman,Andrea C. Carrano,Philip D. Jeffrey,Zachary Bowen,Elspeth Kinnucan,Michael S. Finnin,Stephen J. Elledge,J. Wade Harper,Michele Pagano,Nikola P. Pavletich +9 more
TL;DR: The structure raises the possibility that different Skp1 family members evolved to function with different subsets of F-box proteins, and suggests that the F- box protein may not only recruit substrate, but may also position it optimally for the ubiquitination reaction.
Journal ArticleDOI
Structure of the histone deacetylase SIRT2
TL;DR: The 1.7 Å crystal structure of the 323 amino acid catalytic core of human SIRT2, a homolog of yeast Sir2, reveals an NAD-binding domain, which is a variant of the Rossmann fold, and a smaller domain composed of a helical module and a zinc-binding module.
Journal ArticleDOI
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Woo S. Joo,Philip D. Jeffrey,Sharon B. Cantor,Michael S. Finnin,David M. Livingston,Nikola P. Pavletich +5 more
TL;DR: Analysis of human BRCA1 tumor-derived mutations and conservation identifies a potential protein-binding site that is involved in BACH1 binding, and shows a remarkable conservation of the repeat arrangement and of the inter-BRCT repeat interface.
Patent
Crystal structure of a deacetylase and inhibitors thereof
Nikola P. Pavletich,Michael S. Finnin,Jill R. Donigian,Victoria M. Richon,Richard A. Rifkind,Paul A. Marks,Ronald Breslow +6 more
TL;DR: In this article, the authors provided three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP).