N
Nikola P. Pavletich
Researcher at Howard Hughes Medical Institute
Publications - 9
Citations - 3890
Nikola P. Pavletich is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Binding site & Ubiquitin. The author has an hindex of 7, co-authored 9 publications receiving 3732 citations. Previous affiliations of Nikola P. Pavletich include Memorial Sloan Kettering Cancer Center & Columbia University.
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Journal ArticleDOI
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Michael S. Finnin,Jill R. Donigian,Alona Cohen,Victoria M. Richon,Richard A. Rifkind,Paul A. Marks,Ronald Breslow,Nikola P. Pavletich +7 more
TL;DR: The structure of the histone deacetylase catalytic core is described, as revealed by the crystal structure of a homologue from the hyperthermophilic bacterium Aquifex aeolicus, and it is established that the residues that make up the active site and contact the inhibitors are conserved across the HDAC family.
Journal ArticleDOI
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Michael Ohh,Cheol Won Park,Cheol Won Park,Mircea Ivan,Michael A. Hoffman,Tae-You Kim,Tae-You Kim,L. Eric Huang,Nikola P. Pavletich,Nikola P. Pavletich,Vincent Chau,William G. Kaelin,William G. Kaelin +12 more
TL;DR: It is shown that pVHL, through its β-domain, binds directly to hypoxia-inducible factor (HIF), thereby targeting HIF for ubiquitination in an α-domain-dependent manner, the first function to be ascribed to the pV HL β- domain.
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Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP
TL;DR: The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E 2F and DP proteins both have a fold related to the winged-helix DNA- binding motif.
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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Bing Hao,Bing Hao,Ning Zheng,Brenda A. Schulman,Geng Wu,Julie J. Miller,Michele Pagano,Nikola P. Pavletich,Nikola P. Pavletich +8 more
TL;DR: The structure and biochemical data support the proposed model that Cdk2-cyclin A contributes to the recruitment of p27(Kip1) to the SCF(Skp2)-Cks1 complex.
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Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1
Yentram Huyen,Yentram Huyen,Philip D. Jeffrey,W. Brent Derry,Joel H. Rothman,Nikola P. Pavletich,Nikola P. Pavletich,Elena S. Stavridi,Thanos D. Halazonetis,Thanos D. Halazonetis +9 more
TL;DR: The three-dimensional structure of the Cep-1 DNA binding domain in the absence of DNA is solved and it is compared to that of human p53, which has similar overall folds.