N
Nina Kishimoto
Researcher at University of California, San Francisco
Publications - 5
Citations - 940
Nina Kishimoto is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Islet & Cell type. The author has an hindex of 4, co-authored 5 publications receiving 835 citations.
Papers
More filters
Journal ArticleDOI
Serotonin regulates pancreatic beta cell mass during pregnancy.
Hail Kim,Yukiko Toyofuku,Francis C. Lynn,Francis C. Lynn,Eric W Chak,Toyoyoshi Uchida,Hiroki Mizukami,Yoshio Fujitani,Ryuzo Kawamori,Takeshi Miyatsuka,Yasuhiro Kosaka,Katherine Yang,Gerard Honig,Marieke van der Hart,Nina Kishimoto,Juehu Wang,Soroku Yagihashi,Laurence H. Tecott,Hirotaka Watada,Michael S. German +19 more
TL;DR: An integrated signaling pathway linking beta cell mass to anticipated insulin need during pregnancy is revealed and modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes.
Journal ArticleDOI
Rfx6 directs islet formation and insulin production in mice and humans
Stuart Smith,Hui-Qi Qu,Nadine Taleb,Nina Kishimoto,David W. Scheel,Yang Lu,Ann-Marie Patch,Rosemary Grabs,Juehu Wang,Francis C. Lynn,Francis C. Lynn,Takeshi Miyatsuka,John J. Mitchell,Rina Seerke,Julie Désir,Serge Vanden Eijnden,Marc Abramowicz,Nadine Kacet,Jacques Weill,Marie Éve Renard,Mattia Gentile,Inger Hansen,Ken Dewar,Andrew T. Hattersley,Rennian Wang,Maria E. Wilson,Jeffrey D. Johnson,Constantin Polychronakos,Michael S. German +28 more
TL;DR: It is shown that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3, a unique position for RFX6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans.
Journal ArticleDOI
Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
Yasuharu Ohta,Yasuhiro Kosaka,Nina Kishimoto,Juehu Wang,Stuart Smith,Gerard Honig,Hail Kim,Rosa Gasa,Rosa Gasa,Nicole Neubauer,Angela Liou,Laurence H. Tecott,Evan S. Deneris,Michael S. German +13 more
TL;DR: These studies demonstrate that a common transcriptional cascade drives the differentiation of β-cells and serotonergic neurons and imparts the shared ability to produce serotonin.
Journal ArticleDOI
A mouse model for monitoring islet cell genesis and developing therapies for diabetes.
Yoshinori Shimajiri,Yasuhiro Kosaka,David W. Scheel,Francis C. Lynn,Nina Kishimoto,Juehu Wang,Shuhong Zhao,Michael S. German +7 more
TL;DR: A transgenic mouse line is developed in which the surrogate markers secreted alkaline phosphatase (SeAP) and enhanced green florescent protein (EGFP) can be used to monitor neurogenin-3 expression, and thus islet cell genesis in vivo and developing therapies that induce this process.
Patent
Method for identifying pancreatic progenitor cells
TL;DR: In this paper, methods and compositions relating to the use of Rfx6 for identifying or inducing the differentiation of various cell types in the islet cell lineage are presented, which may include identifying a pancreatic progenitor cell in a population of isolated cells.