L
Laurence H. Tecott
Researcher at University of California, San Francisco
Publications - 93
Citations - 12598
Laurence H. Tecott is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Serotonin & Receptor. The author has an hindex of 53, co-authored 93 publications receiving 11979 citations. Previous affiliations of Laurence H. Tecott include Stanford University & University of California.
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Journal ArticleDOI
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
Laurence H. Tecott,Linda M. Sun,Susan F. Akana,A. M. Strack,Daniel H. Lowenstein,Mary F. Dallman,David Julius +6 more
TL;DR: It is shown that 5-HT2C receptor-deficient mice are overweight as a result of abnormal control of feeding behaviour, establishing a role for this receptor in the serotonergic control of appetite.
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Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Baoji Xu,Evan H. Goulding,Keling Zang,David Cepoi,Roger D. Cone,Kevin R. Jones,Laurence H. Tecott,Louis F. Reichardt +7 more
TL;DR: It is reported that BDNF is expressed at high levels in the ventromedial hypothalamus (VMH) where its expression is regulated by nutritional state and by MC4R signaling, and this results show that MC 4R signaling controls BDNF expression in the VMH.
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Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice
Lora K. Heisler,Hung-Ming Chu,Thomas J. Brennan,Jean A. Danao,Preetpaul Bajwa,Loren H. Parsons,Laurence H. Tecott +6 more
TL;DR: In this paper, the authors used gene-targeting technology to generate 5-HT1A receptor-mutant mice and found that these mutants exhibited a consistent pattern of responses indicative of elevated anxiety levels in open field, elevated zero maze, and novel object assays.
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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.
Vijay K. Yadav,Franck Oury,Nina Suda,Zhong-Wu Liu,Xiao-Bing Gao,Cyrille Confavreux,Kristen C. Klemenhagen,Kenji F. Tanaka,Kenji F. Tanaka,Jay A. Gingrich,X. Edward Guo,Laurence H. Tecott,J. John Mann,René Hen,Tamas L. Horvath,Gerard Karsenty +15 more
TL;DR: This study modifies the map of leptin signaling in the brain and identifies a molecular basis for the common regulation of bone and energy metabolisms.
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Serotonin regulates pancreatic beta cell mass during pregnancy.
Hail Kim,Yukiko Toyofuku,Francis C. Lynn,Francis C. Lynn,Eric W Chak,Toyoyoshi Uchida,Hiroki Mizukami,Yoshio Fujitani,Ryuzo Kawamori,Takeshi Miyatsuka,Yasuhiro Kosaka,Katherine Yang,Gerard Honig,Marieke van der Hart,Nina Kishimoto,Juehu Wang,Soroku Yagihashi,Laurence H. Tecott,Hirotaka Watada,Michael S. German +19 more
TL;DR: An integrated signaling pathway linking beta cell mass to anticipated insulin need during pregnancy is revealed and modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes.