M
Michael Schulte
Researcher at Merck KGaA
Publications - 87
Citations - 1871
Michael Schulte is an academic researcher from Merck KGaA. The author has contributed to research in topics: Ionic liquid & Simulated moving bed. The author has an hindex of 21, co-authored 82 publications receiving 1758 citations. Previous affiliations of Michael Schulte include Merck & Co..
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Particle packed columns and monolithic columns in high-performance liquid chromatography-comparison and critical appraisal.
TL;DR: The review highlights the fundamentals and the most prominent achievements in the field of high-performance liquid chromatography (HPLC) column development over a period of nearly 50 years and treats the major steps and processes in the manufacture of a particle packed column.
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Preparative enantioseparation by simulated moving bed chromatography
Michael Schulte,Jochen Strube +1 more
TL;DR: Simulated moving bed (SMB) chromatography was invented in the 1960s in the petrochemical industry and has since then been widely used to produce petrochemicals and sugars at the multi-ton scale.
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Applying metagenomics for the identification of bacterial cellulases that are stable in ionic liquids
Julia Pottkämper,Peter Barthen,Peter Barthen,Nele Ilmberger,Ulrich Schwaneberg,Alexander Schenk,Michael Schulte,Nikolai Ignatiev,Wolfgang R. Streit +8 more
TL;DR: Improved cellulase variants of CelA10 were isolated in a directed evolution experiment employing SeSaM-technology and analysis of these variants revealed that the N-terminal cellulose binding domain plays a pivotal role for IL resistance.
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Metagenomic cellulases highly tolerant towards the presence of ionic liquids—linking thermostability and halotolerance
Nele Ilmberger,Diana Meske,Julia Juergensen,Michael Schulte,Peter Barthen,Ulrich Rabausch,Angel Angelov,Markus Mientus,Wolfgang Liebl,Ruth A. Schmitz,Wolfgang R. Streit +10 more
TL;DR: Data suggest that IL tolerance appears to correlate with thermophilicity and halotolerance, and the discovery of novel bacterial enzymes with elevated stability in ILs is suggested.
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Two step capture and purification of IgG2 using multicolumn countercurrent solvent gradient purification (MCSGP).
Thomas Müller-Späth,Lars Aumann,Guido Ströhlein,Henri Kornmann,Pascal Valax,Lydia Delegrange,E. Charbaut,Gianni Baer,A. Lamproye,Matthias Jöhnck,Michael Schulte,Massimo Morbidelli +11 more
TL;DR: A two‐step chromatography process for monoclonal antibody (mAb) purification from clarified cell culture supernatant (cCCS) was developed using cation exchange Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) as a capture step.