Romas Skudas

TL;DR: The review highlights the fundamentals and the most prominent achievements in the field of high-performance liquid chromatography (HPLC) column development over a period of nearly 50 years and treats the major steps and processes in the manufacture of a particle packed column.

TL;DR: In this paper, the characterization of porous materials having pore widths in the macropore range of 50 nm to 500 μm has been discussed and the reliability of the use of mercury porosimetry is discussed along with the conditions required for its safe use.

TL;DR: In this paper, the authors summarized the principal aims, content and conclusions of a document recently submitted to IUPAC, as a Technical Report, by the Working Group on "Liquid intrusion and alternative methods for the characterization of macroporous materials" and published in full in Pure and Applied Chemistry.

TL;DR: The complexity and abundance range of biological systems in combination with the extreme purity requirements for drug manufacturing are the challenges that can be mastered today by chromatography, after more than a century of research and development.

TL;DR: The data suggest that mercury intrusion/extrusion porosimetry does not only allow to obtain a comprehensive pore structure analysis, but can also serve as a tool to estimate the mass transport properties of silica monoliths to be employed in liquid-phase separation processes.