M
Michael Sendtner
Researcher at University of Würzburg
Publications - 286
Citations - 34780
Michael Sendtner is an academic researcher from University of Würzburg. The author has contributed to research in topics: Ciliary neurotrophic factor & Neurotrophic factors. The author has an hindex of 88, co-authored 269 publications receiving 31409 citations. Previous affiliations of Michael Sendtner include Hoffmann-La Roche & Regeneron.
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Journal ArticleDOI
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis
Alice Brockington,Paul R. Heath,Hazel Holden,Paul R. Kasher,Florian L.P. Bender,Filip Claes,Diether Lambrechts,Michael Sendtner,Peter Carmeliet,Pamela J. Shaw +9 more
TL;DR: Downregulation of these genes involved in axon outgrowth and synapse formation in adult mice suggests a hitherto unrecognized role of VEGF in the maintenance of neuronal circuitry.
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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
Patrick Lüningschrör,Georg Werner,Stijn Stroobants,Soichiro Kakuta,Benjamin Dombert,Daniela Sinske,Renate Wanner,Renate Lüllmann-Rauch,Benedikt Wefers,Wolfgang Wurst,Rudi D'Hooge,Yasuo Uchiyama,Michael Sendtner,Christian Haass,Christian Haass,Paul Saftig,Bernd Knöll,Anja Capell,Markus Damme +18 more
TL;DR: The data provide mechanistic insight into how TMEM106B affects lysosomal proteolysis and degradative capacity in neurons and implicate TMEM 106B in mediating the axonal transport of LAMP1-positive organelles in motoneurons and axonal sorting at the initial segment.
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Mechanisms of axonal degeneration in EAE—lessons from CNTF and MHC I knockout mice
TL;DR: The results from these studies indicate that the trigger attack for axonal injury even in a well-defined experimental design can be multi-faceted, and may be of importance for future therapeutic strategies.
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hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons.
Michael Briese,Lena Saal-Bauernschubert,Changhe Ji,Mehri Moradi,Hanaa Ghanawi,Michael Uhl,Silke Appenzeller,Rolf Backofen,Michael Sendtner +8 more
TL;DR: It is proposed that 7SK, in addition to its role in transcriptional regulation, acts in concert with hnRNP R to sort specific transcripts into axons to regulate its function in axon maintenance.
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Insulin-like growth factor 1 in diabetic neuropathy and amyotrophic lateral sclerosis.
TL;DR: Strategies aiming at circumventing these inhibitory effects of IGF-1 could be of benefit for development of new therapies for ALS and DNP, but these strategies have to be built on a better understanding of the metabolic processes that contribute to neurodegeneration.