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Paul R. Heath
Researcher at University of Sheffield
Publications - 126
Citations - 7027
Paul R. Heath is an academic researcher from University of Sheffield. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Astrocyte. The author has an hindex of 43, co-authored 126 publications receiving 5873 citations. Previous affiliations of Paul R. Heath include Utrecht University & Royal Hallamshire Hospital.
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Journal ArticleDOI
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo
Duncan Baker,Neil J. Harrison,Edna Maltby,Kath Smith,Harry Moore,Pamela J. Shaw,Paul R. Heath,Hazel Holden,Peter W. Andrews +8 more
TL;DR: It is proposed that the changes observed in HESCs in culture reflect tumorigenic events that occur in vivo, particularly in testicular germ cell tumors, supporting a link between culture adaptation and malignancy.
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The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins
Paul Harrison,Paul R. Heath,Sharon L. Eastwood,Philip W.J. Burnet,Brendan McDonald,R.C.A. Pearson +5 more
TL;DR: Brain pH declined with increasing age at death and was related to agonal state severity, but was independent of postmortem interval and the histological presence of hypoxic changes, and provides a simple means to improve human brain gene expression studies.
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Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis
Paul R. Heath,Pamela J. Shaw +1 more
TL;DR: There is a body of evidence implicating glutamatergic toxicity as a contributory factor in the selective neuronal injury occurring in amyotrophic lateral sclerosis (ALS) as mentioned in this paper.
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Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).
Laura E. Cox,Laura Ferraiuolo,Emily F. Goodall,Paul R. Heath,Adrian Higginbottom,Heather Mortiboys,Hannah Hollinger,Judith Hartley,Alice Brockington,Christine Burness,Karen E. Morrison,Stephen B. Wharton,Andrew J. Grierson,Paul G. Ince,Janine Kirby,Pamela J. Shaw +15 more
TL;DR: In a population drawn from North of England pathogenic CHMP2B mutations are found in approximately 1% of cases of ALS and 10% of those with lower motor neuron predominant ALS, indicating the likely pathogenicity of the reported gene alterations.
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Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.
TL;DR: The changes described in the motor neuron transcriptome evolving during the disease course highlight potential novel targets for neuroprotective therapeutic intervention.