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Michael Sorkin

Researcher at University of Michigan

Publications -  83
Citations -  3883

Michael Sorkin is an academic researcher from University of Michigan. The author has contributed to research in topics: Stem cell & Mesenchymal stem cell. The author has an hindex of 29, co-authored 80 publications receiving 3263 citations. Previous affiliations of Michael Sorkin include New York University & University of Texas Southwestern Medical Center.

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Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.

TL;DR: It is reported that physical force regulates fibrosis through inflammatory FAK–ERK–MCP-1 pathways and that molecular strategies targeting FAK can effectively uncouple mechanical force from pathologic scar formation.
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Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.

TL;DR: Wounds treated with MSC-seeded hydrogels demonstrated significantly enhanced angiogenesis, which was associated with increased levels of VEGF and other angiogenic cytokines within the wounds.
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Surgical Approaches to Create Murine Models of Human Wound Healing

TL;DR: This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.
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Stem cell recruitment after injury: lessons for regenerative medicine

TL;DR: The function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells are discussed.
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CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling.

TL;DR: This work enriched for an osteogenic subpopulation of cells derived from human subcutaneous adipose tissue utilizing microfluidic-based single cell transcriptional analysis and fluorescence-activated cell sorting to illuminate the functional relevance of hASC heterogeneity and enhance understanding of CD105 with respect to osteogenic differentiation.