M
Michael Sorkin
Researcher at University of Michigan
Publications - 83
Citations - 3883
Michael Sorkin is an academic researcher from University of Michigan. The author has contributed to research in topics: Stem cell & Mesenchymal stem cell. The author has an hindex of 29, co-authored 80 publications receiving 3263 citations. Previous affiliations of Michael Sorkin include New York University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.
Victor W. Wong,Kristine C. Rustad,Satoshi Akaishi,Michael Sorkin,Jason P. Glotzbach,Michael Januszyk,Emily R. Nelson,Kemal Levi,Josemaria Paterno,Ivan N. Vial,Anna A. Kuang,Michael T. Longaker,Geoffrey C. Gurtner +12 more
TL;DR: It is reported that physical force regulates fibrosis through inflammatory FAK–ERK–MCP-1 pathways and that molecular strategies targeting FAK can effectively uncouple mechanical force from pathologic scar formation.
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Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.
Kristine C. Rustad,Victor W. Wong,Michael Sorkin,Jason P. Glotzbach,Melanie R. Major,Jayakumar Rajadas,Michael T. Longaker,Geoffrey C. Gurtner +7 more
TL;DR: Wounds treated with MSC-seeded hydrogels demonstrated significantly enhanced angiogenesis, which was associated with increased levels of VEGF and other angiogenic cytokines within the wounds.
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Surgical Approaches to Create Murine Models of Human Wound Healing
TL;DR: This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.
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Stem cell recruitment after injury: lessons for regenerative medicine
TL;DR: The function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells are discussed.
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CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling.
Benjamin Levi,Derrick C. Wan,Jason P. Glotzbach,Jeong S. Hyun,Michael Januszyk,Daniel T. Montoro,Michael Sorkin,Aaron W. James,Emily R. Nelson,Shuli Li,Natalina Quarto,Min Lee,Geoffrey C. Gurtner,Michael T. Longaker +13 more
TL;DR: This work enriched for an osteogenic subpopulation of cells derived from human subcutaneous adipose tissue utilizing microfluidic-based single cell transcriptional analysis and fluorescence-activated cell sorting to illuminate the functional relevance of hASC heterogeneity and enhance understanding of CD105 with respect to osteogenic differentiation.