M
Melanie R. Major
Researcher at Stanford University
Publications - 20
Citations - 847
Melanie R. Major is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Self-healing hydrogels. The author has an hindex of 9, co-authored 16 publications receiving 685 citations. Previous affiliations of Melanie R. Major include Massachusetts Institute of Technology & Johns Hopkins University.
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Journal ArticleDOI
Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.
Kristine C. Rustad,Victor W. Wong,Michael Sorkin,Jason P. Glotzbach,Melanie R. Major,Jayakumar Rajadas,Michael T. Longaker,Geoffrey C. Gurtner +7 more
TL;DR: Wounds treated with MSC-seeded hydrogels demonstrated significantly enhanced angiogenesis, which was associated with increased levels of VEGF and other angiogenic cytokines within the wounds.
Journal ArticleDOI
Engineered Pullulan–Collagen Composite Dermal Hydrogels Improve Early Cutaneous Wound Healing
Victor W. Wong,Kristine C. Rustad,Michael G. Galvez,Evgenios Neofytou,Jason P. Glotzbach,Michael Januszyk,Melanie R. Major,Michael Sorkin,Michael T. Longaker,Jayakumar Rajadas,Geoffrey C. Gurtner +10 more
TL;DR: Using salt-induced phase inversion techniques can be used to create modifiable pullulan-collagen composite dermal scaffolds that augment early wound healing and can potentially serve as a structured delivery template for cells and biomolecules in regenerative skin applications.
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The foreign body response: at the interface of surgery and bioengineering.
TL;DR: Recent basic science studies suggest a role for immune and inflammatory pathways at the implant-host interface that drive the foreign body response, and current strategies that aim to modulate the host response and improve construct biocompatibility appear promising.
Journal ArticleDOI
Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds.
Victor W. Wong,Kristine C. Rustad,Jason P. Glotzbach,Michael Sorkin,Mohammed Inayathullah,Melanie R. Major,Michael T. Longaker,Jayakumar Rajadas,Geoffrey C. Gurtner +8 more
TL;DR: It is shown that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high-oxidative-stress environments.
Journal ArticleDOI
Conceptual design study for heat exhaust management in the ARC fusion pilot plant
Adam Kuang,N. M. Cao,Alexander Creely,Cody A. Dennett,J. Hecla,Brian LaBombard,Roy Tinguely,E.A. Tolman,H. Hoffman,Melanie R. Major,J. Ruiz Ruiz,Dan Brunner,Piyush Grover,Christopher R. Laughman,Brandon Sorbom,D.G. Whyte +15 more
TL;DR: Sorbom et al. as mentioned in this paper extended the ARC pilot plant conceptual design study to explore options for managing ∼525 MW of fusion power generated in a compact, high field tokamak that is approximately the size of JET.